Efficacy of Serologic Marker Screening in Identifying Hepatitis B Virus Infection in Organ, Tissue, and Cell Donors  Dominique Challine, Stéphane Chevaliez, Jean–Michel Pawlotsky  Gastroenterology  Volume 135, Issue 4, Pages 1185-1191 (October 2008) DOI: 10.1053/j.gastro.2008.07.011 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Amino acid sequence alignment of the major hydrophilic region (in squares) HBsAg in the 29 donors in whom the full-length preS1–preS2-S gene could be amplified, including 23 donors with detectable HBsAg, 2 donors with isolated anti-HBc antibodies, 3 donors with both HBsAg and anti-HBs antibodies, and the donor with isolated anti-HBs antibodies. The “a” determinant sequence (amino acids 124–147) is underlined at the top. The sequences are aligned relative to an HBV genotype A prototype sequence, together with prototype sequences of genotypes A–H. The donors' genotypes are indicated in parentheses. Amino acid positions previously reported to bear substitutions associated with HBsAg detection failure in HBV-DNA–positive patients are shown in gray. Amino acid substitutions observed at these positions in the donors of this study are shown in bold letters. Gastroenterology 2008 135, 1185-1191DOI: (10.1053/j.gastro.2008.07.011) Copyright © 2008 AGA Institute Terms and Conditions