Plasma Glucose Homeostasis Widmaier et al., p. 567-580 Glucose metabolism Hormonal Control Disruptions of glucose homeostasis Case Study

Homeostasis of Plasma Glucose Concentration Normal physiological range: 65-100 mg/dl What is the set point? Why is too much plasma glucose harmful? Plasma glucose concentration = glucose entering the plasma – glucose leaving the plasma What are the mechanisms that regulate plasma glucose concentration? What are the components of the negative feedback loop: Glucose receptors? Afferent pathway? Integrator? Efferent pathway(s)? Effector organ(s)? Phases: *absorptive, *post-absorptive, and fasting

Absorptive Phase Fig. 16.01 =sink Hepatic Portal System Lipoprotein Lipase Absorptive Phase 16.01.jpg Hepatic Portal System Once inside, glucose is converted to something else, thereby maintaining a concentration gradient for facilitated diffusion of glucose into cells.