Understanding Different Molecular Mechanisms Involved in Schizophrenia

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Presentation transcript:

Understanding Different Molecular Mechanisms Involved in Schizophrenia Amanda Atrash

Disrupted-In-Schizophrenia-1 (DISC1) Protein Acts as a scaffold 20XX

Nuclear Distribution Element-like 1 (NDEL1) Protein Involved in neuroplasticity Relationship with DISC1 20XX

Does knockout of one protein affect the function of the other? How does knockout of NDEL1 lead to changes in plasticity and dendrite formation in the brain? Disruption of DISC1 via knockout of NDEL1 stunts spine formation in the hippocampus region of mice

Are proteins binded together?

Process of Immunoprecipitation, https://goo.gl/images/R0BoLG

Knockout NDEL1

Are proteins in right place? Focused on hippocampus region, colocalization

Confocal Imaging Vinegoni et al. (2015)

Golden et al. (2013), results

Spine Formation → Schizophrenia Drug Treatment

References