Figure 3 Decreased AHI1 in human CD4+ T cells is associated with decreased proliferation and increased IFNγ production Decreased AHI1 in human CD4+ T cells.

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Figure 3 Decreased AHI1 in human CD4+ T cells is associated with decreased proliferation and increased IFNγ production Decreased AHI1 in human CD4+ T cells is associated with decreased proliferation and increased IFNγ production (A) Naive CD4+ T cells were isolated from the peripheral blood of healthy subjects bearing risk (TT), protective (AA), or heterozygous (AT) alleles for rs4896153, and cells were activated with anti-CD3/CD28 followed by the analysis of cell proliferation by [3H]-thymidine incorporation 60 hours after stimulation. (B, C) A subset of these cells was further stimulated for 7 days, and IFNγ cytokine expression was measured by flow cytometry. (B) Frequency of CD4+IFNγ+ T cells bearing risk (TT) or protective (AA) alleles for the rs4896153 was analyzed by intracellular staining using flow cytometry. (C) Mean fluorescent intensity (MFI) of IFNγ expression from the activated T cells is shown. p Values were generated using Student's t test. Each dot represents an individual. Data are represented as mean ± SEM. IFNγ = interferon gamma. Belinda J. Kaskow et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e414 Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology