Low-Grade Adenosquamous Carcinoma of the Breast: Imaging and Histopathologic Characteristics of This Rare Disease Elena P. Scali, MD, Rola H. Ali, MD,

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Low-Grade Adenosquamous Carcinoma of the Breast: Imaging and Histopathologic Characteristics of This Rare Disease Elena P. Scali, MD, Rola H. Ali, MD, Malcolm Hayes, MD, Scott Tyldesley, MD, Patricia Hassell, MD Canadian Association of Radiologists Journal Volume 64, Issue 4, Pages 339-344 (November 2013) DOI: 10.1016/j.carj.2012.09.002 Copyright © 2013 Canadian Association of Radiologists Terms and Conditions

Figure 1 (A) Mammograms, showing ill-defined asymmetry (arrow) of the retroareolar region of the left breast, without the presence of a definite mass. (B) The normal-appearing right breast is shown for comparison. Canadian Association of Radiologists Journal 2013 64, 339-344DOI: (10.1016/j.carj.2012.09.002) Copyright © 2013 Canadian Association of Radiologists Terms and Conditions

Figure 2 Mammograms, showing malignant-type calcifications (arrow) in the left breast on medial lateral oblique view. Canadian Association of Radiologists Journal 2013 64, 339-344DOI: (10.1016/j.carj.2012.09.002) Copyright © 2013 Canadian Association of Radiologists Terms and Conditions

Figure 3 Radiograph of biopsy specimen from the left breast, showing a round mass (short arrows) with well-defined margins and benign calcifications (long arrow) detected on screening mammography. Canadian Association of Radiologists Journal 2013 64, 339-344DOI: (10.1016/j.carj.2012.09.002) Copyright © 2013 Canadian Association of Radiologists Terms and Conditions

Figure 4 Mammogram of the right breast, showing a mass with spiculated borders (arrow) on medial lateral oblique view. Canadian Association of Radiologists Journal 2013 64, 339-344DOI: (10.1016/j.carj.2012.09.002) Copyright © 2013 Canadian Association of Radiologists Terms and Conditions

Figure 5 Mammogram of the right breast, showing a well-defined oval mass laterally with spiculated appearance medially (arrow). Canadian Association of Radiologists Journal 2013 64, 339-344DOI: (10.1016/j.carj.2012.09.002) Copyright © 2013 Canadian Association of Radiologists Terms and Conditions

Figure 6 (A) Mammogram, showing a spiculated mass (arrow) in the retroareolar region of the right breast on the medial lateral oblique view. (B) Ultrasound image of the right breast, showing an irregular hypoechoic mass with spiculated superior border and dense, posterior acoustic shadowing (arrow). Canadian Association of Radiologists Journal 2013 64, 339-344DOI: (10.1016/j.carj.2012.09.002) Copyright © 2013 Canadian Association of Radiologists Terms and Conditions

Figure 7 Sagittal ultrasound, showing an oval-shaped, multilobulated, hypoechoic lesion, with sharply defined borders. Canadian Association of Radiologists Journal 2013 64, 339-344DOI: (10.1016/j.carj.2012.09.002) Copyright © 2013 Canadian Association of Radiologists Terms and Conditions

Figure 8 Ultrasound of the right breast in transverse view, showing a round, hypoechoic, homogeneous mass with indistinct margins (arrow). Canadian Association of Radiologists Journal 2013 64, 339-344DOI: (10.1016/j.carj.2012.09.002) Copyright © 2013 Canadian Association of Radiologists Terms and Conditions

Figure 9 (A) Right breast transverse ultrasound, showing a round mass with circumscribed, lobular margins, and internal cystic areas (arrow). (B) Needle core biopsy using hematoxylin and eosin stain, showing scattered benign-looking glands (arrows), which may be misinterpreted as normal mammary glands. (C) High-power view of low-grade adenosquamous carcinoma, showing the glandular component (black arrow) and squamous component (blue arrow). Magnification: (B) ×4; (C) ×40. This figure is available in colour online at http://carjonline.org/. Canadian Association of Radiologists Journal 2013 64, 339-344DOI: (10.1016/j.carj.2012.09.002) Copyright © 2013 Canadian Association of Radiologists Terms and Conditions