L. M. Downey, T. J. Keen, E. Roberts, D. C. Mansfield, M. Bamashmus, C

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A New Locus for Autosomal Dominant Familial Exudative Vitreoretinopathy Maps to Chromosome 11p12-13 L.M. Downey, T.J. Keen, E. Roberts, D.C. Mansfield, M. Bamashmus, C.F. Inglehearn The American Journal of Human Genetics Volume 68, Issue 3, Pages 778-781 (March 2001) DOI: 10.1086/318790 Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 1 Haplotypes for 31 members of the large pedigree with autosomal dominant FEVR. Blackened symbols indicate affected individuals; blackened bars indicate the disease haplotype. The proximal crossover is seen in individual IV:5 and was detected by D11S4102 and other markers more proximal to it. The distal crossover is in individual II:15 and was detected by marker GATA34E08 and another, more-distal marker. The American Journal of Human Genetics 2001 68, 778-781DOI: (10.1086/318790) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 2 Chromosome 11 ideogram showing the approximate positions of genes implicated in various retinal phenotypes, mapped according to their distance from the 11p telomere. Distances are composites derived from the databases of Retnet, OMIM, and the Centre for Medical Genetics, Marshfield Medical Research Foundation. AA = locus for atrophia areata; BBS1 = locus for Bardet-Biedl syndrome locus; EVR1 = locus for autosomal dominant familial exudative vitreoretinopathy locus; EVR3 = locus for the new locus described in the present article; MYO7A = locus for Usher syndrome 1B; ROM1 = gene involved in digenic and, possibly, in dominant retinitis pigmentosa; USH1C = locus for Usher syndrome 1C; and VNR1 = locus for autosomal dominant inflammatory vitreoretinopathy. The American Journal of Human Genetics 2001 68, 778-781DOI: (10.1086/318790) Copyright © 2001 The American Society of Human Genetics Terms and Conditions