Combined treatment with celecoxib and sevoflurane after global cerebral ischaemia has no additive neuroprotective effects in rats J.H. Seo, H.P. Park,

Slides:

Advertisements

Similar presentations

TNF-α- Mediated-p38-Dependent Signaling Pathway Contributes to Myocyte Apoptosis in Rats Subjected to Surgical Trauma Cell Physiol Biochem 2015;35:

Advertisements

Aprotinin improves kidney function and decreases tubular cell apoptosis and proapoptotic signaling after renal ischemia-reperfusion Ajay Kher, MD, Kirstan.

MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice Shrikant R. Mulay, Dana Thomasova, Mi Ryu,

Effectiveness of sugammadex for cerebral ischemia/reperfusion injury

Pentoxifylline Alleviates Perinatal Hypoxic-Ischemia-Induced Short-term Memory Impairment by Suppressing Apoptosis in the Hippocampus of Rat Pups Je Hoon.

Zoledronate Inhibits Intimal Hyperplasia in Balloon-injured Rat Carotid Artery L. Wu, L. Zhu, W.H. Shi, B. Yu, D. Cai European Journal of Vascular and.

K. Mertens, D. A. Lowes, N. R. Webster, J. Talib, L. Hall, M. J

Blockade of spinal nerves inhibits expression of neural growth factor in the myocardium at an early stage of acute myocardial infarction in rats W. Yue,

Does the type of fluid affect rapidity of shock reversal in an anaesthetized-piglet model of near-fatal controlled haemorrhage? A randomized study C.

Tumor necrosis factor-α and the early vein graft

G.-T. Shin, D.R. Kim, J.-E. Lim, H. Yim, H. Kim Kidney International

Sevoflurane therapy for life-threatening asthma in children

Isoflurane-induced myocardial preconditioning is dependent on phosphatidylinositol-3- kinase/Akt signalling J. Raphael, J. Rivo, Y. Gozal British Journal.

Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions M. Deng, R.D.

Z. Y. Yu, J. Geng, Z. Q. Li, Y. B. Sun, S. L. Wang, J. Masters, D. X

AnestAssist British Journal of Anaesthesia

Characteristics of pain in hospitalized medical patients, surgical patients, and outpatients attending a pain management centre M.P. Rockett, G. Simpson,

Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats Keisuke Morimoto, MD, Tomomi Hasegawa,

Vein adaptation to arterialization in an experimental model

J.R. Liu, C. Baek, X.H. Han, P. Shoureshi, S.G. Soriano

Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury Lihong Fan, MD, Kunzheng.

Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor- kappa B pathway in neuroglioma cells L. Zhang, J. Zhang, L. Yang,

Volume 67, Issue 1, Pages (January 2005)

L. Tong, M. Cai, Y. Huang, H. Zhang, B. Su, Z. Li, H. Dong

Sevoflurane Attenuates Ischemia-Reperfusion Injury in a Rat Lung Transplantation Model Akihiro Ohsumi, MD, Katherine Marseu, MD, Peter Slinger, MD, Karen.

T. Annecke, D. Chappell, C. Chen, M. Jacob, U. Welsch, C. P

Endothelial progenitor cells attenuate the lung ischemia/reperfusion injury following lung transplantation via the endothelial nitric oxide synthase pathway

Differential effects of serum from patients administered distinct anaesthetic techniques on apoptosis in breast cancer cells in vitro: a pilot study

JNK mediates hepatic ischemia reperfusion injury

Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions J.P. Cata, H. Wang, V. Gottumukkala, J. Reuben,

Renoprotective immunosuppression by pioglitazone with low-dose cyclosporine in rat heart transplantation Yosuke Tanaka, MD, Tomomi Hasegawa, MD, PhD,

J.-Y. Hwang, H.-S. Na, Y.-T. Jeon, Y.-J. Ro, C.-S. Kim, S.-H. Do

Volume 42, Issue 3, Pages (March 2005)

Volume 26, Issue 1, Pages (March 2019)

Inhibition of MicroRNA-204 Conducts Neuroprotection Against Spinal Cord Ischemia Lihui Yan, MD, Enyi Shi, MD, PhD, Xiaojing Jiang, MD, PhD, Jiang Shi,

Seung-Kee Min, MD, PhD, Richard D. Kenagy, PhD, Joseph P

Potential neuroprotective benefits of erythropoietin during experimental hypothermic circulatory arrest Pekka Romsi, MDa, Erkka Rönkä, MSa, Kai Kiviluoma,

Delayed inhaled carbon monoxide mediates the regression of established neointimal lesions Michael Madigan, MD, Fateh Entabi, MD, Brian Zuckerbraun, MD,

Volume 63, Issue 5, Pages (May 2003)

L. -C. Chu, M. -L. Tsaur, C. -S. Lin, Y. -C. Hung, T. -Y. Wang, C. -C

Timing of xenon-induced delayed postconditioning to protect against spinal cord ischaemia–reperfusion injury in rats Y.W. Yang, W.P. Cheng, J.K. Lu,

M. Iwata, S. Inoue, M. Kawaguchi, H. Furuya

Volume 41, Issue 6, Pages (December 2004)

Incidence of postoperative nausea and vomiting after paediatric strabismus surgery with sevoflurane or remifentanil–sevoflurane A.Y. Oh, J.H. Kim, J.W.

Sevoflurane post-conditioning increases nuclear factor erythroid 2-related factor and haemoxygenase-1 expression via protein kinase C pathway in a rat.

Genetic deficiency of adiponectin protects against acute kidney injury

Volume 85, Issue 4, Pages (April 2014)

Relationship between early postoperative C-reactive protein elevation and long-term postoperative major adverse cardiovascular and cerebral events in.

Post-conditioning by a short administration of desflurane reduced renal reperfusion injury after differing of ischaemia times in rats D. Obal, K. Rascher,

Magnesium sulphate as a technique of hypotensive anaesthesia

Predictive factors of symptomatic cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in adult patients with.

Anaesthesia for peculiar cells'a century of sickle cell disease

Randomized comparison of the Pentax AirWay Scope and Macintosh laryngoscope for tracheal intubation in patients with obstructive sleep apnoea M.K. Kim,

Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients: a systematic review R. Adams, G.T. Brown, M. Davidson,

Optimizing cerebral oxygenation in anaesthetized patients with carotid artery stenosis: the influence of inspired oxygen fraction P. Picton, S.K. Ramachandran,

Sustained effect of spinal cord stimulation on pain and quality of life in painful diabetic peripheral neuropathy R. Slangen, W.A. Pluijms, C.G. Faber,

Efficacy of butylscopolamine for the treatment of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study

Sevoflurane preconditioning-induced neuroprotection is associated with Akt activation via carboxy-terminal modulator protein inhibition Y. Chen, H. Nie,

Aged erythrocytes: a fine wine or sour grapes?

J Lee, S Gupta, C Price, A.P. Baranowski

Chronic widespread pain, including fibromyalgia: a pathway for care developed by the British Pain Society J. Lee, B. Ellis, C. Price, A.P. Baranowski

Pharmacological perioperative brain neuroprotection: a qualitative review of randomized clinical trials F. Bilotta, A.W. Gelb, E. Stazi, L. Titi, F.P.

P.E. Vlisides, M.S. Avidan, G.A. Mashour

Helium-induced late preconditioning in the rat heart in vivo†

Fig. 4. Comparison of the apoptotic indices across the groups

Voltage changes in the lithium dilution cardiac output sensor after exposure to blood from horses given xylazine T.D. Ambrisko, Y. Moens British Journal.

C.M. Chalmers, A.M. Bal British Journal of Anaesthesia

Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing.

R. Parke, S. McGuinness, R. Dixon, A. Jull

Activated protein C inhibits chemotaxis and interleukin-6 release by human neutrophils without affecting other neutrophil functions H.F. Galley, N.E.

Presentation transcript:

Combined treatment with celecoxib and sevoflurane after global cerebral ischaemia has no additive neuroprotective effects in rats J.H. Seo, H.P. Park, Y.T. Jeon, Y.J. Lim, K. Nam, J.W. Hwang British Journal of Anaesthesia Volume 110, Issue 6, Pages 988-995 (June 2013) DOI: 10.1093/bja/aet009 Copyright © 2013 The Author(s) Terms and Conditions

Fig 1 Experimental protocol for transient global cerebral IR injury in rats. After IR insults, celecoxib 2 mg kg−1 or sevoflurane 2.4% were administered according to group assignments. Occlusion=bilateral common carotid arteries occlusion with systemic hypotension. British Journal of Anaesthesia 2013 110, 988-995DOI: (10.1093/bja/aet009) Copyright © 2013 The Author(s) Terms and Conditions

Fig 2 (a) Representative photomicrographs of hippocampal CA1 stained with H&E 7 days after transient global cerebral ischaemia in rats. Viable cells have round and pale-stained nuclei, whereas necrotic cells have pyknotic or karyolytic nuclei and show cytoplasmic shrinkage. Magnification is ×400. Scale bar=10 μm. (b) Percentages of necrotic cells in the hippocampal CA1 7 days after ischaemia. Results are median, interquartile, and full ranges (n=4 in the sham group and n=10 in the other groups). *P<0.001 compared with the sham group. †P<0.05 compared with the control group. CA1, Cornu Ammonis area 1. British Journal of Anaesthesia 2013 110, 988-995DOI: (10.1093/bja/aet009) Copyright © 2013 The Author(s) Terms and Conditions

Fig 3 (a) Representative photomicrographs of TUNEL assay in the hippocampal CA1 of rats 7 days after transient global cerebral ischaemia. TUNEL-positive cells with dark brown colour indicate apoptotic cells. Magnification is ×400. Scale bar=10 μm. (b) Percentages of apoptotic cells in the hippocampal CA1 7 days after ischaemia. Results are median, interquartile, and full ranges (n=4 in the sham group and n=10 in the other groups). *P<0.001 compared with the sham group. †P<0.05 compared with the control group. TUNEL, terminal deoxynucleotidyl transferase-mediated deoxy-uracil triphosphate biotin in situ nick end labelling; CA1, Cornu Ammonis area 1. British Journal of Anaesthesia 2013 110, 988-995DOI: (10.1093/bja/aet009) Copyright © 2013 The Author(s) Terms and Conditions

Fig 4 Serum TNF-α (a) and IL-1β (b) 2 h, 3 and 7 days after transient global cerebral ischaemia in rats. Results are median, interquartile, and full ranges (n=4 in the sham group and n=10 in the other groups). *P<0.001 compared with the sham group 2 h after ischaemia. †P<0.05 compared with the control group 2 h after ischaemia. ‡P<0.05 compared with the sham group 3 or 7 days after ischaemia. TNF-α, tumour necrosis factor-α; IL-1β, interleukin-1β. British Journal of Anaesthesia 2013 110, 988-995DOI: (10.1093/bja/aet009) Copyright © 2013 The Author(s) Terms and Conditions