Active-Site Dynamics in RNA Polymerases

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Active-Site Dynamics in RNA Polymerases Robert Landick Cell Volume 116, Issue 3, Pages 351-353 (February 2004) DOI: 10.1016/S0092-8674(04)00121-7

Figure 1 Active-Site Dynamics in RNAPs (A) The four states of the T7 RNAP nucleotide addition cycle. These views are illustrative approximations of the crystal structures described by Yin and Steitz (2004)(this issue of Cell) and Temiakov et al. (2004)(this issue of Cell). P, product site (sometimes called i site in msRNAPs). S, substrate site (sometimes called i+1 site in msRNAPs). Yellow spheres depict Mg2+ ions, which are coordinated by phosphates, active-site residues, or (in the preinsertion state) Y639 and NTP 2′ OH groups. (B) The bridge helix conformations of bacterial RNAP and yeast RNAPII, depicted as proposed for helix-distortion-driven translocation. Cell 2004 116, 351-353DOI: (10.1016/S0092-8674(04)00121-7)