Knemometry is more sensitive to systemic effects of inhaled corticosteroids in children with asthma than 24-hour urine cortisol excretion Bo Chawes,

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Presentation transcript:

Knemometry is more sensitive to systemic effects of inhaled corticosteroids in children with asthma than 24-hour urine cortisol excretion Bo Chawes, MD, PhD, DMSc, Erik Nilsson, MD, Sarah Nørgaard, MSc, Anna Dossing, MD, Li Mortensen, MD, Hans Bisgaard, MD, DMSc Journal of Allergy and Clinical Immunology Volume 140, Issue 2, Pages 431-436 (August 2017) DOI: 10.1016/j.jaci.2016.09.041 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Study group flowchart. Journal of Allergy and Clinical Immunology 2017 140, 431-436DOI: (10.1016/j.jaci.2016.09.041) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 LLGR assessed by means of knemometry by the parametric 2 leg LLGR4×4 method during the baseline placebo run-in period versus the ICS treatment periods. The horizontal black line shows the mean LLGR (n = 43). Journal of Allergy and Clinical Immunology 2017 140, 431-436DOI: (10.1016/j.jaci.2016.09.041) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Twenty-four-hour UFC/creatinine excretion ratio for the baseline placebo run-in period versus the ICS treatment period. The horizontal black line shows the mean UFC/creatinine excretion ratio (n = 43). Journal of Allergy and Clinical Immunology 2017 140, 431-436DOI: (10.1016/j.jaci.2016.09.041) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Relationship between the number of required children in future knemometry studies (y-axis) to obtain a power of 80% plotted against mean difference in mean LLGR per week (x-axis) for the parametric 2 leg method (LLGR4×4) and the nonparametric 1 leg method (LLGR2×2). Journal of Allergy and Clinical Immunology 2017 140, 431-436DOI: (10.1016/j.jaci.2016.09.041) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions