CD4+CXCR5+IL-4+ TFH cells and CD4+IL-4+BATF+ T cells are enriched in IgG4-RD, and their proportions are tightly linked to serum IgG4 levels and IgG4-positive.

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CD4+CXCR5+IL-4+ TFH cells and CD4+IL-4+BATF+ T cells are enriched in IgG4-RD, and their proportions are tightly linked to serum IgG4 levels and IgG4-positive plasma cells. CD4+CXCR5+IL-4+ TFH cells and CD4+IL-4+BATF+ T cells are enriched in IgG4-RD, and their proportions are tightly linked to serum IgG4 levels and IgG4-positive plasma cells. (A) Quantification of CD4+CXCR5+IL-4+ and CD4+CXCR5+ TFH cells in 17 IgG4- RD SMGs, seven SS LSGs, 12 tonsils, two cervical lymph nodes, and three mesenteric lymph nodes. The P-value is based on the Mann–Whitney U test. (B) Correlations of the proportion of CD4+CXCR5+IL-4+ TFH cells and CD4+BATF+IL-4+ T cells in SMGs from patients with IgG4-RD and their serum IgG, IgA, IgE, IgM, or IgG4 levels. The r and P-value were determined using Spearman’s rank correlations. (C) Correlations of the proportions of CD4+CXCR5+IL-4+ TFH cells in SMGs from patients with IgG4-RD and their ratio of IgG4+/IgG+ cells (n = 17). The r and P-value were determined using Spearman’s rank correlations. (D) The frequency of CD4+CXCR5+IL-4+ TFH cells in SMGs from patients with IgG4-RD (n = 17) correlated with the frequency of CD4+BATF+IL-4+ T cells and serum IgG4 concentrations. The r and P-value were determined using Spearman’s rank correlations. Takashi Maehara et al. LSA 2018;1:e201800050 © 2018 Maehara et al.