Oxidative stress in stable cystic fibrosis patients: Do we need higher antioxidant plasma levels? Antonela Lezo, Fiorella Biasi, Paola Massarenti, Roberto.

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Presentation transcript:

Oxidative stress in stable cystic fibrosis patients: Do we need higher antioxidant plasma levels? Antonela Lezo, Fiorella Biasi, Paola Massarenti, Roberto Calabrese, Giuseppe Poli, Bruna Santini, Elisabetta Bignamini Journal of Cystic Fibrosis Volume 12, Issue 1, Pages 35-41 (January 2013) DOI: 10.1016/j.jcf.2012.06.002 Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Effect of age on plasma chromolipids. 4‐hydroxynonenal and malonaldehyde are expressed as HNE‐L/mg cholesterol and MDA‐L/mg cholesterol respectively. ρs: Spearman rank correlation coefficient. Journal of Cystic Fibrosis 2013 12, 35-41DOI: (10.1016/j.jcf.2012.06.002) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Correlation between chromolipids and antioxidant vitamin plasma levels. Upper panel: correlation between 4‐hydroxynonenal (HNE‐L/cholesterol) and plasma levels of vitamin E (A), vitamin A (B), vitamin C (C). Lower pane: correlation between malonaldehyde (MDA‐L/cholesterol) and plasma levels of vitamin E (D), vitamin A (E), vitamin C (F). ρs, Spearman rank correlation coefficient. Journal of Cystic Fibrosis 2013 12, 35-41DOI: (10.1016/j.jcf.2012.06.002) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Antioxidant vitamins and oxidative stress markers in presence and absence of PI. Chromolipids in patients with PI (1) and without PI (0): HNE‐L/cholesterol (left panel) and MDA‐L/cholesterol (right panel). Journal of Cystic Fibrosis 2013 12, 35-41DOI: (10.1016/j.jcf.2012.06.002) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions