Nat. Rev. Nephrol. doi: /nrneph

Slides:

Advertisements

Similar presentations

Biochemical Markers in the inflammatory response Dr Claire Bethune Consultant Immunologist Derriford Hospital.

Advertisements

PROFESSIONAL ANTIGEN PRESENTING CELLS

 Transplantation is the process of taking cells, tissues, or organs, called a,graft, from one individual and placing them into a different individual.

Activation of T Lymphocytes

Pattern recognition receptors (PRRs)

Inflammation (1 of 5) Ali Al Khader, M.D. Faculty of Medicine

Thymocyte development summary

Figure 2 Cell-mediated disease mechanisms of lupus nephritis

Nat. Rev. Clin. Oncol. doi: /nrclinonc

Figure 3 Neutrophils in liver inflammation

Figure 4 Interactions between adipose, the microbiome and kidney

Figure 1 Radiation-induced effects on tumour cells

Figure 5 Dendritic cells in liver inflammation

Figure 3 Proposed mechanisms underlying the links

T cell mediated immunity

Nat. Rev. Nephrol. doi: /nrneph

The Th17 immune response in renal inflammation

Nat. Rev. Nephrol. doi: /nrneph

Figure 3 TNFSF activities enhancing immune cell activation

Microvascular responses to sepsis: clinical significance

Nat. Rev. Cardiol. doi: /nrcardio

Figure 3 Molecular mechanisms of crystal-induced necroinflammation

Figure 1 Innate immune responses in atherosclerosis

Malaria Vaccine Design: Immunological Considerations

Figure 2 Roles of mTOR complexes in the kidney

Nat. Rev. Nephrol. doi: /nrneph

Figure 3 The mechanism of injury in ACLF

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Emerging models of antibody-mediated rejection (ABMR) and

Figure 3 Cascade of events leading from AKI to ALI

Richard L. Gallo, Jamie J. Bernard

From immunosuppression to tolerance

Respiratory syncytial virus (RSV) infection and the host.

Nat. Rev. Endocrinol. doi: /nrendo

Nat. Rev. Nephrol. doi: /nrneph

Arming Treg Cells at the Inflammatory Site

Figure 4 TNFSF inflammatory activities in tissue cells

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

during the alloimmune response

Figure 3 Current model of immunopathogenesis in CIDP

Figure 3 Pathological activation of complement

Figure 2 Pro-inflammatory and anti-inflammatory effects of the gut microbiota Figure 2 | Pro-inflammatory and anti-inflammatory effects of the gut microbiota.

Figure 3 Biologics that attenuate effector responses in the kidney

Jo-Ellen Murphy, Caroline Robert, Thomas S. Kupper

Inflammatory health effects of indoor and outdoor particulate matter

Nat. Rev. Nephrol. doi: /nrneph

Figure 1 Principal pathogenic mechanisms of

Figure 1 Mechanisms of oncolytic-virus-based cancer therapy

Figure 2 Adaptive immunity in atherosclerosis

Figure 2 The hypoxia-induced proinflammatory

Anti-inflammatory Agents: Present and Future

Figure 1 Sequence of events in the development of autoimmune nephritis

Adiponectin: an enlarging role in acute kidney injury

Azucena Ramos, Michael T. Hemann Cell

Azucena Ramos, Michael T. Hemann Cell

Figure 2 Initiators of obesity-associated inflammation in adipocytes

Immune reconstitution inflammatory syndrome (IRIS) associated with Mycobacterium tuberculosis (TB) infection. a) In healthy individuals in response to.

Figure 4 Role of chemokines in dendritic cell migration

Basophils and mast cells in renal injury

Paola Romagnani, Hans-Joachim Anders Kidney International

Volume 71, Issue 12, Pages (June 2007)

Proposed mechanisms for fibrointimal proliferation in pulmonary tumour thrombotic microangiopathy (PTTM). Proposed mechanisms for fibrointimal proliferation.

Figure 1 The role of macrophages in RA

Chemokines: Key Players in Innate and Adaptive Immunity

Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell–mediated allergic inflammation Yong-Jun Liu, MD, PhD Journal.

Nat. Rev. Rheumatol. doi: /nrrheum

Damage-associated molecular pattern (DAMP)-induced activation of Toll-like receptors (TLRs). Damage-associated molecular pattern (DAMP)-induced activation.

Wolbachia-induced responses of specific cell types.

Figure 1. Initiation of vasculitic lesions in small vessels by ANCA-activating cytokine-primed neutrophils in the wrong place and at the wrong time. Figure.

Predicted sequence of events in O. volvulus/Wolbachia-induced keratitis. Predicted sequence of events in O. volvulus/Wolbachia-induced keratitis. Wolbachia.

Presentation transcript:

Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.41 Figure 1 Inflammation initiation and maintenance after organ transplantation Figure 1 | Inflammation initiation and maintenance after organ transplantation. Ischaemia–reperfusion injury (IRI) induces a degree of graft cell necrosis and breakdown of the extracellular matrix. These processes lead to the release of damage-associated molecular patterns (DAMPs), which can heighten the intragraft inflammatory milieu by activating innate immune signalling pathways via the toll-like receptors (TLR). Graft cells (vascular endothelial cells, macrophages and dendritic cells) upregulate adhesion molecules (such as VCAM-1 and L-selectin) and co-stimulatory molecules (such as CD80). They also secrete inflammatory cytokines (such as IL-6 and TNF), which enhance immune cell recruitment into the graft and activate activate recipient cells to produce amplifiers of inflammation such as haptoglobin, which enter the circulation and amplify inflammation within the transplant. This increased inflammation further activates graft resident or infiltrated immune cells and induces their migration to the draining lymph nodes where they can activate naive anti-donor T cells to initiate adaptive anti-donor immune responses. The inflammatory reaction triggered by IRI can ultimately lead to graft rejection. Goldstein, D. R. et al. (2016) Role of TLRs and DAMPs in allograft inflammation and transplant outcomes Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.41