Free Radical-Mediated Tissue Injury in Acute Lung Allograft Rejection and the Effect of Superoxide Dismutase Takeshi Shiraishi, Ataru Kuroiwa, Takayuki.

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Free Radical-Mediated Tissue Injury in Acute Lung Allograft Rejection and the Effect of Superoxide Dismutase Takeshi Shiraishi, Ataru Kuroiwa, Takayuki Shirakusa, Katsunobu Kawahara, Satoshi Yoneda, Keiko Kitano, Kan Okabayashi, Akinori Iwasaki The Annals of Thoracic Surgery Volume 64, Issue 3, Pages 821-825 (September 1997) DOI: 10.1016/S0003-4975(97)00754-6

Fig. 1 Relative luminol-dependent chemiluminescence (CL) response of peripheral blood from allograft recipient (BN to F344) during acute rejection. Each value was expressed as a percentage of the peak CL count against that of normal F344 rat. (Data plotted represent average value of three experiments.) The Annals of Thoracic Surgery 1997 64, 821-825DOI: (10.1016/S0003-4975(97)00754-6)

Fig. 2 The level of lipid peroxide in lung allograft (Allo.) was compared with syngeneic graft (Syng.) on day 7 after transplantation (D-7) when complete graft rejection would be expected in this combination. The values were expressed as total malondialdehyde (MDA) levels in whole allograft tissue (mean ± standard error). A significant difference was seen between allogenic graft and syngeneic graft (p < 0.05). The Annals of Thoracic Surgery 1997 64, 821-825DOI: (10.1016/S0003-4975(97)00754-6)

Fig. 3 Radiographic aeration score (score 0 = opaque lung to score 6 = normal-appearing lung) on superoxide dismutase-treated (black squares) and untreated (white squares) allograft recipients. At each time point, there was no significant difference between groups. The value was expressed as mean ± standard error. The Annals of Thoracic Surgery 1997 64, 821-825DOI: (10.1016/S0003-4975(97)00754-6)

Fig. 4 In superoxide dismutase-treated (black bars) or untreated (white bars) groups of allograft recipients, acute rejection was evaluated histologically and assigned a rejection score based on the clinical international working formulation (grade A0 = no significant abnormality to grade A4 = diffuse perivascular, interstitial, and air space infiltration of mononuclear cells). The value was expressed as mean ± standard deviation. The Annals of Thoracic Surgery 1997 64, 821-825DOI: (10.1016/S0003-4975(97)00754-6)