Kenneth E.L. McColl, Derek Gillen  Gastroenterology 

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Evidence That Proton-Pump Inhibitor Therapy Induces the Symptoms it Is Used to Treat  Kenneth E.L. McColl, Derek Gillen  Gastroenterology  Volume 137, Issue 1, Pages 20-22 (July 2009) DOI: 10.1053/j.gastro.2009.05.015 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 The increased gastrin concentration during proton-pump inhibitor therapy exerts trophic effects on the oxyntic mucosa causing hyperplasia and increased functional capacity of the enterochromaffin-like (ECL) cell and parietal cell. As a consequence, on discontinuing the proton-pump inhibitor there is rebound acid hypersecretion which persists for at least 2 months. Gastroenterology 2009 137, 20-22DOI: (10.1053/j.gastro.2009.05.015) Copyright © 2009 AGA Institute Terms and Conditions

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