Figure 3 Genetic pleiotropy in ALS Figure 3 | Genetic pleiotropy in ALS. Several genetic variants associated with amyotrophic lateral sclerosis (ALS) are also associated with frontotemporal dementia (FTD). In this stalagmite plot, the size of each plotted point is in direct proportion to the number of publications on ALS and FTD that reference the gene specified. The position on the x-axis corresponds to the proportion of publications in ALS and FTD. Al-Chalabi, A. et al. (2016) Gene discovery in amyotrophic lateral sclerosis: implications for clinical management Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.182