Combinatorial Haplo-Deficient Tumor Suppression in 7q-Deficient Myelodysplastic Syndrome and Acute Myeloid Leukemia Britta Will, Ulrich Steidl Cancer.

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Presentation transcript:

Combinatorial Haplo-Deficient Tumor Suppression in 7q-Deficient Myelodysplastic Syndrome and Acute Myeloid Leukemia Britta Will, Ulrich Steidl Cancer Cell Volume 25, Issue 5, Pages 555-557 (May 2014) DOI: 10.1016/j.ccr.2014.04.018 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Leukemogenic Cooperation of Mll3 and Nf1 Haploinsufficiency in a p53-Deficient Background Adoptive transfer of lentivirally transduced hematopoietic stem and progenitor cells (HSPCs) into syngeneic recipient animals leads to an AML recapitulating hallmarks of human −7/7q- AML, in contrast to thymic lymphoma induced by p53 deficiency only. Cancer Cell 2014 25, 555-557DOI: (10.1016/j.ccr.2014.04.018) Copyright © 2014 Elsevier Inc. Terms and Conditions