Increase in the Prevalence of Atrophic Gastritis Among Adults Age 35 to 44 Years Old in Northern Sweden Between 1990 and 2009  Huan Song, Maria Held, Sven Sandin, Hilpi Rautelin, Mats Eliasson, Stefan Söderberg, Göran Hallmans, Lars Engstrand, Olof Nyrén, Weimin Ye  Clinical Gastroenterology and Hepatology  Volume 13, Issue 9, Pages 1592-1600.e1 (September 2015) DOI: 10.1016/j.cgh.2015.04.001 Copyright © 2015 AGA Institute Terms and Conditions

Figure 1 Flowchart of the selection procedure of the study population. PR, participation rate. Clinical Gastroenterology and Hepatology 2015 13, 1592-1600.e1DOI: (10.1016/j.cgh.2015.04.001) Copyright © 2015 AGA Institute Terms and Conditions

Figure 2 Observed prevalence of PG-I–defined functional ACG across different survey occasions, stratified by age group (10-year strata). ACG was defined by a serum PG-I concentration less than 28 μg/L (measured by the Gastroset PG-I assay) for samples from the 1990, 1994, and 1999 survey occasions, and less than 45 μg/L (measured by the PG-I Enzyme-Linked Immunosorbent Assay Kit) for samples from the 2004 and 2009 survey occasions. In a validation study, the agreement of the 2 kits was proved to be high (κ = 0.80). Clinical Gastroenterology and Hepatology 2015 13, 1592-1600.e1DOI: (10.1016/j.cgh.2015.04.001) Copyright © 2015 AGA Institute Terms and Conditions

Figure 3 Age-specific secular trends in proportions of H pylori and CagA seropositivity among subjects involved in the case–control analysis (n = 1219), across the 5 survey occasions during 1990 to 2009. (A) The secular trends in the proportion of H pylori seropositivity, stratified by age group. (B) The secular trends in the proportion of CagA seropositivity, stratified by age group. Clinical Gastroenterology and Hepatology 2015 13, 1592-1600.e1DOI: (10.1016/j.cgh.2015.04.001) Copyright © 2015 AGA Institute Terms and Conditions

Supplementary Figure 1 Plots of Bland–Altman analysis comparison of PG-I obtained in 2002 using the Gastroset PG-I assay and PG-I measured in 2013 using the PG-I Enzyme-Linked Immunosorbent Assay Kit (n = 894). (A) Plot of identity and (B) Bland-Altman plot. Clinical Gastroenterology and Hepatology 2015 13, 1592-1600.e1DOI: (10.1016/j.cgh.2015.04.001) Copyright © 2015 AGA Institute Terms and Conditions

Supplementary Figure 2 The prevalence of obesity (BMI ≥ 30 kg/m2) among all studied populations (n = 5283) across the 5 survey occasions, stratified by age group (10-year strata). Clinical Gastroenterology and Hepatology 2015 13, 1592-1600.e1DOI: (10.1016/j.cgh.2015.04.001) Copyright © 2015 AGA Institute Terms and Conditions