Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen Maria-Helena Terrien, MD, François Rahm, MD, Jean-Marc.

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Presentation transcript:

Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen Maria-Helena Terrien, MD, François Rahm, MD, Jean-Marc Fellrath, MD, François Spertini, MD Journal of Allergy and Clinical Immunology Volume 103, Issue 6, Pages 1025-1030 (June 1999) DOI: 10.1016/S0091-6749(99)70174-0 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 1 Shifts in allergen concentration for each patient after terfenadine or fexofenadine treatment compared with the screening phase. Results are expressed as the number of shifts in allergen concentration over the screening phase to reach the combined reaction threshold (terfenadine vs fexofenadine, P = .033 [chi-square trend]). Journal of Allergy and Clinical Immunology 1999 103, 1025-1030DOI: (10.1016/S0091-6749(99)70174-0) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 2 Cumulative patient-response curve for combined threshold expressed as the percent of patients reaching combined reaction threshold at each allergen concentration (terfenadine vs fexofenadine, P = .021 [chi-square trend]). Journal of Allergy and Clinical Immunology 1999 103, 1025-1030DOI: (10.1016/S0091-6749(99)70174-0) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 3 Cumulative patient-response curves for (A) nasal secretion threshold (0.5 g secretion over 10 minutes) (terfenadine vs fexofenadine, P = .008 [chi-square trend]), (B) nasal obstruction threshold as measured by AR (a decrease in at least 30% in MCA), or (C) nasal obstruction threshold as measured by PNIF (a decrease of at least 40% in nasal peak flow) (B and C, terfenadine vs fexofenadine, P > .05 [chi-square trend]). Results are expressed as the percent of patients reaching reaction threshold at each allergen concentration. Journal of Allergy and Clinical Immunology 1999 103, 1025-1030DOI: (10.1016/S0091-6749(99)70174-0) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 4 Symptom scores for nasal itchiness and nasal congestion. Nasal pruritus score (range, 1 to 10) (A) and nasal congestion score (range, 1 to 10) (B) at each allergen concentration. Results are expressed as means ± SEM. Numbers on top of SEM bars indicate number of patients still tested when less than 25. *P < .05, **P < .01, terfenadine or fexofenadine vs screening phase; unpaired Student t test. Journal of Allergy and Clinical Immunology 1999 103, 1025-1030DOI: (10.1016/S0091-6749(99)70174-0) Copyright © 1999 Mosby, Inc. Terms and Conditions