IgE sensitization in relation to preschool eczema and filaggrin mutation Emma Kristin Johansson, MD, Anna Bergström, PhD, Inger Kull, RN, PhD, Tomas Lind,

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

What drives prescription patterns in pediatric asthma management?

Association of physical activity, asthma, and allergies: A cohort of farming and nonfarming children Bettina Bringolf-Isler, MD, PhD, Eva Graf, MD, Marco.

Sangshin Park, DVM, MPH, PhD, Eun-Hee Lee, PhD, Younglim Kho, PhD

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study Anna.

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children Woo Kyung Kim, MD, PhD, Ji-Won Kwon,

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Sara J. Brown, MRCP, Caroline L

Is 9 more than 2 also in allergic airway inflammation?

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study Anna.

Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition

Children with allergic and nonallergic rhinitis have a similar risk of asthma Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,

Mothers' anxiety during pregnancy is associated with asthma in their children Hannah Cookson, MB, ChB, Raquel Granell, PhD, Carol Joinson, PhD, Yoav Ben-Shlomo,

Rising prevalence of asthma is sex-specific in a US farming population

Test for Respiratory and Asthma Control in Kids (TRACK): A caregiver-completed questionnaire for preschool-aged children Kevin R. Murphy, MD, Robert.

Prediction of peanut allergy in adolescence by early childhood storage protein-specific IgE signatures: The BAMSE population-based birth cohort Anna.

Peter M. Wolfgram, MD, David B. Allen, MD

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life

Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts Olena Gruzieva, MD, PhD, Ulrike Gehring, PhD,

Jon Genuneit, MD, MSc Journal of Allergy and Clinical Immunology

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma Ingo Marenholz, PhD, Tamara Kerscher,

Phillip Lieberman, MD, Michael Tankersley, MD

Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children Woo Kyung Kim, MD, PhD, Ji-Won Kwon,

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults Meghan F. Davis, PhD, Roger D. Peng, PhD,

What are the best outcome measurements for atopic eczema

Anna Nowak-Wegrzyn, MD, Katherine A. Bloom, MD, Scott. H

Reduced risk of peanut sensitization following exposure through breast-feeding and early peanut introduction Tracy J. Pitt, MD, Allan B. Becker, MD,

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Increasing rate of hospitalizations for food-induced anaphylaxis in Italian children: An analysis of the Italian Ministry of Health database Rita Nocerino,

Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy Piush J. Mandhane, MD, Justina M. Greene, Dip.

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Jennifer S. Kim, MD, Anna Nowak-Węgrzyn, MD, Scott H

Christine L. M. Joseph, PhD, Dennis R. Ownby, MD, Suzanne L

Medication use in children with asthma in Finland from 1995 to 2006

Polyunsaturated fatty acids in plasma at 8 years and subsequent allergic disease Jessica Magnusson, PhD, Sandra Ekström, MSc, Inger Kull, PhD, Niclas.

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Childhood-to-adolescence evolution of IgE antibodies to pollens and plant foods in the BAMSE cohort Magnus Wickman, MD, PhD, Anna Asarnoj, MD, PhD, Henrike.

Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence Devasmitha Venkataraman, MD, MRCPCH, MSc, Nelís Soto-Ramírez,

Corinne A. Keet, MD, MS, Wayne G. Shreffler, MD, PhD, Roger D

Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study Mònica Guxens, MD, MPH, PhD, Agnes M.M. Sonnenschein–van.

One step forward, 2 steps back: The enigma of preschool wheeze

Day-care attendance, position in sibship, and early childhood wheezing: A population- based birth cohort study Nicolaos C. Nicolaou, MD, MPhil, Angela.

The relationship between vaccine refusal and self-report of atopic disease in children Rachel Enriquez, PhD, Whitney Addington, MD, Faith Davis, PhD,

Association of physical activity, asthma, and allergies: A cohort of farming and nonfarming children Bettina Bringolf-Isler, MD, PhD, Eva Graf, MD, Marco.

Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence Devasmitha Venkataraman, MD, MRCPCH, MSc, Nelís Soto-Ramírez,

Atopic endotype in childhood

Edith Chen, PhD, Madeleine U. Shalowitz, MD, Rachel E

Asthma: The past, future, environment, and costs

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Personal and parental nativity as risk factors for food sensitization

Associations among maternal childhood socioeconomic status, cord blood IgE levels, and repeated wheeze in urban children Michelle J. Sternthal, PhD,

Fish and polyunsaturated fat intake and development of allergic and nonallergic rhinitis Jessica Magnusson, MSc, Inger Kull, PhD, Marit Westman, MD, Niclas.

Increased risk of eczema but reduced risk of early wheezy disorder from exclusive breast-feeding in high-risk infants Charlotte Giwercman, MD, Liselotte.

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Advances in pediatric asthma in 2007

Negative affect, medication adherence, and asthma control in children

Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood Adnan Custovic, MD, PhD, Lars Soderstrom,

Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence Marit Westman, MD, Christian Lupinek,

Natural history of cow’s milk allergy

Ann-Marie M. Schoos, MD, PhD, Bo L

Carl Hamsten, MSc, PhD, Thi Anh T

Presentation transcript:

IgE sensitization in relation to preschool eczema and filaggrin mutation Emma Kristin Johansson, MD, Anna Bergström, PhD, Inger Kull, RN, PhD, Tomas Lind, Cilla Söderhäll, PhD, Marianne van Hage, MD, PhD, Magnus Wickman, MD, PhD, Natalia Ballardini, MD, PhD, Carl-Fredrik Wahlgren, MD, PhD Journal of Allergy and Clinical Immunology Volume 140, Issue 6, Pages 1572-1579.e5 (December 2017) DOI: 10.1016/j.jaci.2017.04.008 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flow chart of the study showing children included in different analyses of IgE sensitization in relation to PSE and FLG mutation. PSE was defined as eczema between 0 and 4 years of age based on questionnaire data. Journal of Allergy and Clinical Immunology 2017 140, 1572-1579.e5DOI: (10.1016/j.jaci.2017.04.008) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Association between PSE and IgE sensitization at 4, 8, and 16 years of age. Children with data on PSE who provided blood at least once were included in the analysis (n = 3201). We used a logistic regression model with GEE adjusted for sex and heredity. Effect modification was tested for sex, heredity, breast-feeding, parental smoking during infancy, mother's age, socioeconomic status, and FLG mutation. B, Association between FLG mutation and IgE sensitization at 4, 8, and 16 years of age. Children from the BAMSE cohort with data on FLG mutation and PSE were included in the analysis (n = 1890). We used a logistic regression model with GEE adjusted for PSE, sex, and heredity. Effect modification was tested for sex, heredity, breast-feeding, parental smoking during infancy, mother's age, socioeconomic status, and PSE. Journal of Allergy and Clinical Immunology 2017 140, 1572-1579.e5DOI: (10.1016/j.jaci.2017.04.008) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Proportions of children with monosensitization, oligosensitization, and polysensitization among IgE-sensitized children with and without PSE at 4, 8, and 16 years of age in the BAMSE cohort. Journal of Allergy and Clinical Immunology 2017 140, 1572-1579.e5DOI: (10.1016/j.jaci.2017.04.008) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Pattern of IgE sensitization at 4 (A), 8 (B), and 16 (C) years of age by PSE. Bars represent the proportions of children in each group with specific IgE ≥0.35 kUA/L for the respective allergen. Children in the BAMSE cohort with any IgE sensitization and complete data on specific IgE measurement at respective ages were included. *Significant differences. Journal of Allergy and Clinical Immunology 2017 140, 1572-1579.e5DOI: (10.1016/j.jaci.2017.04.008) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions