Mutant ftsI genes in the emergence of penicillin-binding proteinmediated β-lactam resistance in Haemophilus influenzae in Norway D. Skaare, A.-G. Allum,

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Mutant ftsI genes in the emergence of penicillin-binding proteinmediated β-lactam resistance in Haemophilus influenzae in Norway D. Skaare, A.-G. Allum, I.L. Anthonisen, A. Jenkins, A. Lia, L. Strand, Y. Tveten, B.-E. Kristiansen Clinical Microbiology and Infection Volume 16, Issue 8, Pages 1117-1124 (August 2010) DOI: 10.1111/j.1469-0691.2009.03052.x Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Neighbour-joining rectangular phylogram of ftsI DNA sequences using the distance method. The outgroup (hpa) is Haemophilus parainfluenzae (AB267856) [15]. The scale is DNA sequence divergence, 0.1 corresponding to 10% divergence. Labelling indicates resistance category (R, resistant; S, susceptible), isolate identification number, pulsed-field gel electrophoresis-based clonal group membership (1–5 or ‘x’ where no clonal affinity is observed) and penicillin-binding protein 3 substitution type (in brackets); A–G for resistant isolates, U–z for susceptible isolates, where z represents the amino acid sequence of Haemophilus influenzae Rd KW20 [14]. Allele designations used in the text are indicated by labelled vertical lines to the right of the strains to which they refer. Clinical Microbiology and Infection 2010 16, 1117-1124DOI: (10.1111/j.1469-0691.2009.03052.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Dendrogram showing pulsed-field gel electrophoresis band patterns. Clustering is according to Dice coefficients of similarity. The dashed line represents 80% similarity. Clonal groups are boxed and resistant isolates are in bold. For detailed explanation of labelling, see Fig. 1. Clinical Microbiology and Infection 2010 16, 1117-1124DOI: (10.1111/j.1469-0691.2009.03052.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions