Figure 1 Evolution of multiple sclerosis

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Figure 1 Evolution of multiple sclerosis Figure 1 | Evolution of multiple sclerosis. Several factors that predispose to multiple sclerosis (MS) are at play during the subclinical phase of the disease, before clinically recognizable symptoms are present. The light blue area represents progression of MS, and bars denote events that cause inflammatory damage to the CNS, some of which do not reach the clinical threshold. Arrows denote episodes of new inflammation in the CNS, recorded by MRI, and are much more frequent than clinical relapses. Olsson, T. et al. (2016) Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.187