Volume 19, Issue 4, Pages (September 2012)

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Volume 19, Issue 4, Pages 299-307 (September 2012) Synaptic degradation of cardiac autonomic nerves in streptozotocin-induced diabetic rats Shamarendra N. Sanyal, Tomoyuki Wada, Motoko Yamabe, Hirofumi Anai, Shinji Miyamoto, Tatsuo Shimada, Katsushige Ono Pathophysiology Volume 19, Issue 4, Pages 299-307 (September 2012) DOI: 10.1016/j.pathophys.2012.08.002 Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Fasting blood sugar (FBS) values of control and diabetic (STZ-DM) groups (A) and body weight (B) in control (vehicle) rats (n=6). #p<0.001 vs. control group. Pathophysiology 2012 19, 299-307DOI: (10.1016/j.pathophys.2012.08.002) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Electrocardiogram (ECG), trendgram of RR intervals and power spectrograms in a control Wistar (vehicle) rat and an STZ-DM rat. Representative ECG records for 1.6s in a control rat (A) and in an STZ-DM rat (B). The trendgram of RR intervals for 10min was obtained from a control (C) and an STZ-DM rat (D). Power spectra of heart rate (RR interval) fluctuations in (E) and (F) were deduced from trendgrams in (C) and (D), respectively. Pathophysiology 2012 19, 299-307DOI: (10.1016/j.pathophys.2012.08.002) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Daily recordings of heart rate (HR) obtained during the control condition (before STZ injection) and after STZ-injection (A), and histograms of averaged heart rate (HR) during control and DM periods for every 20days (B), obtained from (A). The figure also shows the results of daily analyses of total power (C), HF power (E), and L/H power ratio (G). Histograms of their 20-day average (D), (F), and (H) were respectively obtained from (C), (E) and (G). Arrows indicate the day of STZ injection. **p<0.01, #p<0.001 vs. control group (n=6). Pathophysiology 2012 19, 299-307DOI: (10.1016/j.pathophys.2012.08.002) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Electron microscopic structures of sympathetic (A, C, E) and parasympathetic nerve endings (B, D, F) closely located to the SA nodal cells. Panels A and B were from a control rat; C, and D were from an STZ-treated rat at week 4; E and F were from an STZ-treated rat at month 4. a for adrenergic nerve endings containing cored vesicles. c for cholinergic nerve endings containing clear vesicles. 22,000×. Pathophysiology 2012 19, 299-307DOI: (10.1016/j.pathophys.2012.08.002) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions