Relamorelin Relieves Constipation and Accelerates Colonic Transit in a Phase 2, Placebo-Controlled, Randomized Trial Andres Acosta, Michael Camilleri,

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Relamorelin Relieves Constipation and Accelerates Colonic Transit in a Phase 2, Placebo-Controlled, Randomized Trial Andres Acosta, Michael Camilleri, Gururaj Kolar, Johanna Iturrino, Lawrence A. Szarka, Amy Boldingh, Duane Burton, Michael Ryks, Deborah Rhoten, Alan R. Zinsmeister, Sharon C. Spence, Keith Gottesdiener, Ernest P. Bouras, Maria I. Vazquez-Roque Clinical Gastroenterology and Hepatology Volume 13, Issue 13, Pages 2312-2319.e1 (December 2015) DOI: 10.1016/j.cgh.2015.04.184 Copyright © 2015 AGA Institute Terms and Conditions

Figure 1 (A) Study design. (B) CONSORT flow chart. GI, gastrointestinal; sc, subcutaneously. Clinical Gastroenterology and Hepatology 2015 13, 2312-2319.e1DOI: (10.1016/j.cgh.2015.04.184) Copyright © 2015 AGA Institute Terms and Conditions

Figure 2 Bowel movements during baseline and treatment phases. (A) Number of SBMs per week (P < .001), and (B) ease of passage of SBMs (P = .11). Clinical Gastroenterology and Hepatology 2015 13, 2312-2319.e1DOI: (10.1016/j.cgh.2015.04.184) Copyright © 2015 AGA Institute Terms and Conditions

Figure 3 Time to first BM after first treatment dose. (A) Mean ± SEM and (B) cumulative proportion plot for time to first BM (P = .004). Clinical Gastroenterology and Hepatology 2015 13, 2312-2319.e1DOI: (10.1016/j.cgh.2015.04.184) Copyright © 2015 AGA Institute Terms and Conditions