Filling the Interstices

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Filling the Interstices Mary F Dallman Neuron Volume 37, Issue 4, Pages 550-553 (February 2003) DOI: 10.1016/S0896-6273(03)00083-7

Figure 1 Schematic Model of Hormonal Regulation of Food Intake and Energy Storage Two gut-related peptides, ghrelin and insulin, are secreted before and after feeding. Two other hormones reflect the state of energy stores (glucocorticoids [GC] and leptin). Both ghrelin and GC concentrations are elevated in negative energy balance, and both insulin and leptin concentrations are increased in positive energy balance. All four hormones act on orexigenic NPY/AGRP neurons in the arcuate n. of the hypothalamus to either stimulate (solid lines, arrow) or inhibit (dashed lines, line) activity in NPY/AGRP cells and subsequent feeding and energy balance. For clarity, only the effects on NPY cells are shown. Neuron 2003 37, 550-553DOI: (10.1016/S0896-6273(03)00083-7)