Guo-Wei He, MD, PhD, Cheng-Qin Yang, MD

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Presentation transcript:

Comparative study on calcium channel antagonists in the human radial artery: Clinical implications Guo-Wei He, MD, PhD, Cheng-Qin Yang, MD The Journal of Thoracic and Cardiovascular Surgery Volume 119, Issue 1, Pages 94-100 (January 2000) DOI: 10.1016/S0022-5223(00)70222-4 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Mean concentration (–log10 M) response (percentage relaxation) curves for 4 calcium channel antagonists in the human radial artery precontracted by potassium chloride (diltiazem, potassium 25 mmol/L; n = 6 for nicardipine [NIC] , n = 6 for nifedipine [NIF] , and n = 5 for verpamil [VER] and diltiazem [DIL] ). The rings were taken from 4 to 6 patients in each group. Vertical error bars are 1 SEM of mean values. The Journal of Thoracic and Cardiovascular Surgery 2000 119, 94-100DOI: (10.1016/S0022-5223(00)70222-4) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Mean concentration (–log10 M)-contraction (percentage of 100 mmol/L potassium-induced contraction) curves for 4 calcium channel antagonists: nifedipine (NIF, A ), nicardipine (NIC, B ), verapamil (VER, C ), and diltiazem (DIL, D ). Rings taken from the same patient were allocated to each treatment. One ring was the control (filled circles) without pretreatment of calcium antagonists. The second ring was treated with the plasma concentration of the particular calcium channel antagonists (open circles) : 20 nmol/L (–7.7 log10 M) for nifedipine (A) , nicardipine (B) , and verapamil (C) and 60 nmol/L (–7.2 log10 M) for diltiazem (D) . The third ring was treated with a high concentration of the calcium channel antagonists (filled triangles , 30 μmol/L [–4.5 log10 M]), which implies the topical use of the drug. The drug was added into the organ bath 20 minutes before the start of the concentration-contraction curve. Symbols represent data averaged from 6 rings (from 6 patients) for each calcium antagonist. Vertical error bars are 1 SEM of mean values (P = .0002 for nifedipine [A] , P = .003 for nicardipine [B] , P = .9 for verapamil [C] , and P = .5 for diltiazem [D] ; ANOVA). *P < .05; **P < .01; ***P < .001 compared with control (Scheffe F test). The Journal of Thoracic and Cardiovascular Surgery 2000 119, 94-100DOI: (10.1016/S0022-5223(00)70222-4) Copyright © 2000 Mosby, Inc. Terms and Conditions