Heimo Breiteneder, PhD, Christof Ebner, MD

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Presentation transcript:

Molecular and biochemical classification of plant-derived food allergens Heimo Breiteneder, PhD, Christof Ebner, MD Journal of Allergy and Clinical Immunology Volume 106, Issue 1, Pages 27-36 (July 2000) DOI: 10.1067/mai.2000.106929 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Comparison of amino acid sequences of Bet v 1 homologous plant food allergens. Amino acid sequences of plant food allergens from apple (Mal d 1, EMBL/GenBank accession No. P43211), pear (Pyr c 1, AF057030), sweet cherry (Pru av 1, U66076), apricot (Pru ar 1, AF020784), celery (Api g 1, P49372), carrot (Dau c 1, Z84376), parsley (PcPR1, P19417), and potato (pSTH-2, P17624) that are homologous to PR-10 type proteins were aligned. Because the major birch pollen allergen Bet v 1 (P15494) is assumed act as the sensitizing agent, its sequence was used as the reference. In each case the sequence of only one representative variant of the allergen was used. Dashes, Identical residues; dots, gaps in sequences. Asterisks, Identical residues present in all sequences aligned or denoting the end of a sequence. Residues that are identical between fruit allergens are colored in yellow, those between vegetable allergens in green. Journal of Allergy and Clinical Immunology 2000 106, 27-36DOI: (10.1067/mai.2000.106929) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Plant food allergen classes and cross-reactivity: it’s all in the genes. The genetic code stands for homologous DNA sequences that encode such cross-reacting allergens. Allergy to certain plant foods such as apple, carrot, or cherry can be induced by pollen allergens that are homologous to PR-10 type proteins and that are represented by the background of hazel and birch inflorescences. In addition, the antifungal thaumatin-like proteins (PR-5) of apple and cherry have been identified as allergens. Pineapple and kiwi fruit are examples of sources of thiol proteases that can act as allergens. Other proteins that are part of the plant defense system and have been identified as allergens include a prohevein-like protein from turnip (PR-4), chitinases from avocado and banana (PR-3), and LTPs (PR-14) from fruits and seeds. The LTP of barley that survives the malting and brewing process is involved in beer foam formation. Plant food allergens have also been found among inhibitors of proteases and α-amylases from cereals or among a variety of seed storage proteins from peanut or soybean. Journal of Allergy and Clinical Immunology 2000 106, 27-36DOI: (10.1067/mai.2000.106929) Copyright © 2000 Mosby, Inc. Terms and Conditions