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The Nervous System Unit III Module 10.

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Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.92 Figure 3 Pain pathways in health and during chronic inflammatory conditions Figure 3 | Pain pathways in health and during chronic inflammatory conditions. The central panel illustrates how facet, sacroiliac and synovial nociceptors of the peripheral nervous system (PNS) meet in the spinal cord to send a signal to the brain via second-order neurons. a | The relationship between sensorimotor, default mode and salience networks in healthy individuals (left). In patients with chronic pain due to ankylosing spondylitis, interaction between these three networks is altered, including greater cross-network functional connectivity compared to healthy individuals (right). b | The peripheral and central neuroanatomy of pain pathways (red) that link nociceptors to connectomes in the central nervous system (CNS). c | Inflammatory molecules and cells can modulate the pain pathway and the dynamic pain connectome is altered during chronic pain. DAMP, damage-associated molecular patterns; PAMP, pathogen-associated molecular patterns. Bidad, K. et al. (2017) Pain in ankylosing spondylitis: a neuro-immune collaboration Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.92