The case for 0.9% NaCl: is the undefendable, defensible? Can Ince, A.B. Johan Groeneveld  Kidney International  Volume 86, Issue 6, Pages 1087-1095 (December 2014) DOI: 10.1038/ki.2014.193 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Microcirculatory-guided fluid therapy. The goal of fluid therapy is to improve cardiac output with the aim of improving microcirculatory capillary perfusion. Hypovolemia is defined as the condition in which there is reduced capillary convection, which is expected to improve upon fluid administration. Increased capillary perfusion indicates fluid responsiveness. Optimal fluid volume is defined as the condition in which optimal convection of red blood cells (RBC) is achieved in optimally RBC-filled capillaries. Administration of too much fluid dilutes the RBCs in the capillaries, increasing diffusion distances limiting the transport of oxygen. The composition of fluids influences the amount of fluids needed to achieve optimal administered fluid volume. Kidney International 2014 86, 1087-1095DOI: (10.1038/ki.2014.193) Copyright © 2014 International Society of Nephrology Terms and Conditions