Ontogeny of pulmonary cyclooxygenase-1 (COX-1) and -2 (COX-2) Zaher A. Radi, Mark R. Ackermann  Pathophysiology  Volume 18, Issue 3, Pages 215-219 (June 2011) DOI: 10.1016/j.pathophys.2011.01.001 Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 (A) COX-1 expression in the lung from a pre-term lamb at 115 days of gestation. Strong expression in bronchial smooth muscle cells (long arrows) and vascular smooth muscle and endothelial cells (short arrows). (B) COX-1 expression in the lung from a pre-term lamb at 130 days of gestation. Strong expression in bronchial smooth muscle cells (long arrows) and moderate expression in alveolar septa (short arrows). (C) COX-1 expression in the lung from a term lamb at 145 days gestation. Strong expression in bronchial smooth muscle cells (long arrows) and vascular smooth muscle cells (short arrows). (D) COX-1 expression in the lung from a post-natal lamb. Strong expression in bronchial smooth muscle cells (long arrows) and vascular smooth muscle cells (short arrows). Immunohistochemical stain, original magnification 10×. Pathophysiology 2011 18, 215-219DOI: (10.1016/j.pathophys.2011.01.001) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 (A) COX-2 expression in the lung from a pre-term lamb at 115 days of gestation. No expression in any pulmonary microanatomic location. (B) COX-2 expression in the lung from a pre-term lamb at 130 days of gestation. No expression in any pulmonary microanatomic location. (C) COX-2 expression in the lung from a term lamb at 145 days gestation. Mild expression in bronchial (long arrows) and bronchiolar (short arrows) epithelial cells. (D) COX-2 expression in the lung from a post-natal lamb. Mild expression in bronchial and bronchiolar epithelial cells (long arrows). Immunohistochemical stain, original magnification 10×. Pathophysiology 2011 18, 215-219DOI: (10.1016/j.pathophys.2011.01.001) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions