Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice Hirono.

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Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice Hirono Ochi, Toshiro Takai, Sakiko Shimura, Natsuko Maruyama, Izumi Nishioka, Seiji Kamijo, Hideo Iida, Susumu Nakae, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda Journal of Investigative Dermatology Volume 137, Issue 7, Pages 1578-1582 (July 2017) DOI: 10.1016/j.jid.2017.02.970 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Skin treatment with SDS promoted epicutaneous sensitization to papain. (a) Time line. (b, d–f) Papain or (c) ovalbumin (10 mg/ml) was administered onto the surface of both ears with or without (b–e) SDS pretreatment or (f) tape stripping in mice. (b, c) Serum antibodies. (d) Histology. (e, f) Ear swelling. ∗P < 0.05 by (b, c, f) the Mann-Whitney U test and (e) t test. Data represent the mean ± standard deviation of (b) five or (c) 10–11 mice or (e) eight or (f) four ears per group. Scale bar = 50 μm. e.c., epicutaneous administration; OD, optical density; OVA, ovalbumin; SDS, sodium dodecyl sulfate. Journal of Investigative Dermatology 2017 137, 1578-1582DOI: (10.1016/j.jid.2017.02.970) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Responses in IL-33–/– and TSLPR–/– mice in the sensitization phase of the SDS model of epicutaneous papain sensitization and the subsequent effector phase of atopic march in airway. (a, g) Time lines (a for b–f; g for h and i). Papain (10 mg/ml) was administered onto the surface of both ears with or without (b–e, h, i) SDS pretreatment or (f) tape stripping in mice. (b, d–f) Serum antibodies. (c, i) Eosinophilic airway inflammation after intranasal challenge with low-dose papain (2.5 μg). (h) Cytokine release in restimulated skin-draining cervical lymph node cells. ∗P < 0.05 by analysis of variance except for in c (t test). #P < 0.05 in d versus before IN challenge (b) by paired t test. Data represent the mean ± standard deviation of (b–d, f) n = 4–6, (e) n = 4–9, or (i) n = 5–9 mice per group or (h) triplicate culture wells. Detection limits are indicated by dotted lines in h. BAL, bronchial alveolar lavage; DLN, draining lymph node; e.c., epicutaneous sensitization; i.n., intranasal challenge; ns, no significant difference; OD, optical density; TSLPR, TSLP receptor. Journal of Investigative Dermatology 2017 137, 1578-1582DOI: (10.1016/j.jid.2017.02.970) Copyright © 2017 The Authors Terms and Conditions