Screening early renal failure: Cut-off values for serum creatinine as an indicator of renal impairment Cécile Couchoud, Nicole Pozet, Michel Labeeuw,

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Screening early renal failure: Cut-off values for serum creatinine as an indicator of renal impairment Cécile Couchoud, Nicole Pozet, Michel Labeeuw, Claire Pouteil-Noble Kidney International Volume 55, Issue 5, Pages 1878-1884 (May 1999) DOI: 10.1046/j.1523-1755.1999.00411.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Receiver operating characteristic (ROC) curve for serum creatinine in men corresponding to an inulin clearance at 60ml/min/1.73m2. The small square indicates the point where the Younden index is maximum (serum creatinine = 137 μmol/liter). Kidney International 1999 55, 1878-1884DOI: (10.1046/j.1523-1755.1999.00411.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Projections of predictive values for several plausible values of prevalence, with sensitivity at 90% (men at 60ml/min/1.73m2). Symbols are: (•) positive predictive value; (□) negative predictive value. Kidney International 1999 55, 1878-1884DOI: (10.1046/j.1523-1755.1999.00411.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Trade-off between sensitivity and specificity for each level of serum creatinine in men at 60ml/min/1.73m2. The vertical line indicates the point where the Younden index is maximum (serum creatinine = 137 μmol/liter). The lightly dotted line is the Younden index, the medium line is the sensitivity, and the heavy line is the specificity. Kidney International 1999 55, 1878-1884DOI: (10.1046/j.1523-1755.1999.00411.x) Copyright © 1999 International Society of Nephrology Terms and Conditions