Defining the Molecular Landscape of Ependymomas

Slides:



Advertisements
Similar presentations
Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.
Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet
Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.
Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.
The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.
IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.
The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel
Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors Kunyoo Shin, Agnes Lim, Chen.
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.
Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel
Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.
T-ALL: Home Is where the CXCL12 Is
New Views into the Prostate Cancer Genome
Building better therapy for children with acute lymphoblastic leukemia
Kristin G. Anderson, Ingunn M. Stromnes, Philip D. Greenberg 
Intravascular Survival and Extravasation of Tumor Cells
Kenneth L. Scott, Scott Powers  Cancer Cell 
Posterior Fossa Ependymomas: A Tale of Two Subtypes
An Alternative Sugar Fuels AML
Unweaving the Autism Spectrum
Radiotherapy Complements Immune Checkpoint Blockade
Volume 9, Issue 2, Pages (August 2011)
Ana Magalhães, Henrique O. Duarte, Celso A. Reis  Cancer Cell 
Genetic Classification of Gliomas: Refining Histopathology
Michael W.M. Kühn, Scott A. Armstrong  Cancer Cell 
Outcomes of Second-Line Chemotherapy in Patients with Relapsed Extensive Small Cell Lung Cancer  Sandra Froeschl, MD, Garth Nicholas, MD, FRCPC, Victor.
Michael W.M. Kühn, Scott A. Armstrong  Cancer Cell 
Tipping the Balancing ACT
Pontine Infantile Glioma Simplified
Skill Development in Graduate Education
New Views into the Genetic Landscape of Metastatic Breast Cancer
Tumor-Educated Platelets as Liquid Biopsy in Cancer Patients
How To Choose a Good Scientific Problem
Adjuvant chemotherapy for rectal cancer – Authors' reply
Gliomas “Dope Up” for Growth
Copyright © 2012, Elsevier Inc. All rights Reserved.
Targeting T Cell Co-receptors for Cancer Therapy
Cohesin and the Maternal Age Effect
Eukaryotic Transcription Activation: Right on Target
Characterizing the Killer Colorectal Carcinomas
Patterns of Somatically Acquired Amplifications and Deletions in Apparently Normal Tissues of Ovarian Cancer Patients  Leila Aghili, Jasmine Foo, James.
Volume 164, Issue 5, Pages (February 2016)
Copyright © 2013 Elsevier Inc. All rights reserved.
Daniel Morgensztern, MD, Boone Goodgame, MD, Maria Q
Copyright © 2012, Elsevier Inc. All rights Reserved.
Kenneth L. Scott, Scott Powers  Cancer Cell 
Proteins in Plant Brassinosteroid Signaling
From One to Many: Further Refinement of Medulloblastoma Subtypes Offers Promise for Personalized Therapy  Abhishek Bavle, D. Williams Parsons  Cancer.
Patterns of Somatically Acquired Amplifications and Deletions in Apparently Normal Tissues of Ovarian Cancer Patients  Leila Aghili, Jasmine Foo, James.
Genome-Wide SNP Analysis in Cancer: Leukemia Shows the Way
RIPK3 Slams the Brake on Leukemogenesis
Splicing and Dicing MYC-Mediated Synthetic Lethality
Copyright © 2013 Elsevier Inc. All rights reserved.
It’s ALL in the Family: IKZF1 and Hereditary Leukemia
Volume 10, Issue 3, Pages (September 2006)
How To Choose a Good Scientific Problem
Copyright © 2012, Elsevier Inc. All rights Reserved.
There's a Time and a Place for MYCN
Presentation transcript:

Defining the Molecular Landscape of Ependymomas Tenley C. Archer, Scott L. Pomeroy  Cancer Cell  Volume 27, Issue 5, Pages 613-615 (May 2015) DOI: 10.1016/j.ccell.2015.04.015 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 The Two Largest Subgroups of Ependymoma Have the Lowest Overall 5-Year Survival Rates and Are Predominantly Pediatric (A) The overall 5-year survival rates of each subtype are listed as a bar graph. Ependymomas develop in each compartment of the CNS, spine (SP), posterior fossa (PF), and supratenorial (ST), and each compartment has three subtypes of ependymoma. Median age at diagnosis is listed for each subgroup. (B) The frequency of patients in each subgroups of ependymoma as identified in the Pajtler et al. (2015) cohort. PF-EPN-A and ST-EPN-RELA are the most common subtypes of ependymoma. Cancer Cell 2015 27, 613-615DOI: (10.1016/j.ccell.2015.04.015) Copyright © 2015 Elsevier Inc. Terms and Conditions