Volume 53, Issue 4, Pages (April 1998)

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Presentation transcript:

Volume 53, Issue 4, Pages 986-993 (April 1998) Angiotensin converting enzyme inhibitor-induced renal dysfunction in atherosclerotic renovascular disease Peter J.G. van de Ven, Jaap J. Beutler, Dr, Rob Kaatee, Frederik J.A. Beek, Willem P. Th M. Mali, Hein A. Koomans Kidney International Volume 53, Issue 4, Pages 986-993 (April 1998) DOI: 10.1111/j.1523-1755.1998.00840.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Systolic and diastolic blood pressure (A) and plasma creatinine (B) in 12 patients in which angiotensin converting enzyme inhibition (ACEi) caused an increase in plasma creatinine (≥ 20%) only after lowering the blood pressure with a diuretic. Data are presented as median ± quartiles. Kidney International 1998 53, 986-993DOI: (10.1111/j.1523-1755.1998.00840.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Individual changes in plasma creatinine during angiotensin converting enzyme inhibition (ACEi) plotted against the stenosis grade of the best perfused kidney in all 108 patients studied. Symbols are: (□) patients in whom ACEi was stopped after four days since plasma creatinine had increased by ≥ 20% (N = 26); (▴) patients in whom plasma creatinine was measured after addition of diuretics to ACEi to control blood pressure (N = 15); (○) all other patients. Kidney International 1998 53, 986-993DOI: (10.1111/j.1523-1755.1998.00840.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Individual data of plasma creatinine in the absence of angiotensin converting enzyme inhibition (ACEi) in patients with severe bilateral renal artery stenosis (≥ 50% stenosis to the best perfused kidney or to solitary kidney; N = 52) and in the patients with lesser grades or absent renovascular disease (N = 56). For the latter group, patients displaying ≥ 20% increase in plasma creatinine during ACEi (N = 17) have been denoted in closed symbols. Kidney International 1998 53, 986-993DOI: (10.1111/j.1523-1755.1998.00840.x) Copyright © 1998 International Society of Nephrology Terms and Conditions