Suspected Aerogenous Lung Metastases From Nasopharyngeal Cancer

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Presentation transcript:

Suspected Aerogenous Lung Metastases From Nasopharyngeal Cancer Masashi Nagata, MD, Haruhiko Nakayama, MD, PhD, Tomohiko Matsuzaki, MD, Hideyuki Furumoto, MD, Tetsuya Isaka, MD, Teppei Nishii, MD, Madoka Furukawa, MD, Akira Kubota, MD, Hiroyuki Ito, MD, PhD, Tomoyuki Yokose, MD, PhD The Annals of Thoracic Surgery Volume 101, Issue 5, Pages e157-e159 (May 2016) DOI: 10.1016/j.athoracsur.2015.10.093 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 (A) A magnetic resonance image shows that the tumor has invaded the nasopharyngeal wall (yellow arrow). (B, C) Hematoxylin and eosin staining of a biopsy specimen shows a nonkeratinizing carcinoma with lymphocyte infiltration (B, ×80; C, ×200). (D) In situ hybridization shows diffuse positive staining of Epstein-Barr virus mRNA (×200). The Annals of Thoracic Surgery 2016 101, e157-e159DOI: (10.1016/j.athoracsur.2015.10.093) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Chest computed tomography before treatment for nasopharyngeal cancer revealed two small nodules in the right lower lobe of the lung (red arrows). (B–F) Six nodules appeared within 1 year after treatment initiation (red arrows). All the nodules were present in the right lower lobe. The Annals of Thoracic Surgery 2016 101, e157-e159DOI: (10.1016/j.athoracsur.2015.10.093) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A, B) Hematoxylin and eosin staining of a resected lung nodule shows pulmonary metastasis of the nasopharyngeal cancer (A, ×80; B, ×200). (C) In situ hybridization shows diffuse positive staining of Epstein-Barr virus mRNA in all resected lung nodules (×200). (D) An intraalveolar floating cancer cell cluster is separate from the primary tumor (×200). The Annals of Thoracic Surgery 2016 101, e157-e159DOI: (10.1016/j.athoracsur.2015.10.093) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions