Katharine H. Wrighton, Fangyan Dai, Xin-Hua Feng Developmental Cell

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A New Kid on the TGFβ Block: TAZ Controls Smad Nucleocytoplasmic Shuttling Katharine H. Wrighton, Fangyan Dai, Xin-Hua Feng Developmental Cell Volume 15, Issue 1, Pages 8-10 (July 2008) DOI: 10.1016/j.devcel.2008.06.010 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 The Role of TAZ in TGFβ Signaling In the absence of signal, Smads shuttle between the nucleus and cytoplasm without being recruited to the transcriptional machinery. During signal transduction, Smad2/3 are phosphorylated and form a complex with Smad4. TAZ binds to the heteromeric Smad complex to retain Smads in the nucleus, and couples them to transcriptional machinery via the ARC105 subunit of the Mediator complex (MED). TFX, context-dependent transcription factor X that cooperates with Smads; GTF, general transcription factor. Developmental Cell 2008 15, 8-10DOI: (10.1016/j.devcel.2008.06.010) Copyright © 2008 Elsevier Inc. Terms and Conditions