Volume 115, Issue 5, Pages 1056-1061 (November 1998) American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12  Steven R. Brant, Yifan Fu, Carter T. Fields, Romulo Baltazar, Geoffrey Ravenhill, Michael R. Pickles, Patrick M. Rohal, Jasdeep Mann, Barbara S. Kirschner, Ethylin Wang Jabs, Theodore M. Bayless, Stephen B. Hanauer, Judy H. Cho  Gastroenterology  Volume 115, Issue 5, Pages 1056-1061 (November 1998) DOI: 10.1016/S0016-5085(98)70073-3 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Nonparametric multipoint NPL scores plotted as a function of marker distance, in centimorgans from the most p-telomeric marker. The markers used for this analysis are listed in Table 2. Bold line shows data from all families combined, solid line shows data from Ashkenazic families, and dotted line shows data from non-Jewish white families. The names and relative positions of the most p- and q-telomeric markers, and 2 or 3 additional markers in between (including the marker having the greatest evidence for linkage) are given for each chromosomal segment to assist in orientation. P values listed for a marker correspond to the one curve having the greatest NPL score for that marker. Gastroenterology 1998 115, 1056-1061DOI: (10.1016/S0016-5085(98)70073-3) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 2 Sibling pair analysis of chromosome 12, IBD2. Multipoint lod score curve (mls), affected sibling pairs, and exclusion curves for a locus-specific λs of 2.5, 2.0, and 1.5 are shown. A horizontal dotted line extends from the lod score of −2.0 point on the y-axis to demarcate the corresponding level of exclusion for the graph. Gastroenterology 1998 115, 1056-1061DOI: (10.1016/S0016-5085(98)70073-3) Copyright © 1998 American Gastroenterological Association Terms and Conditions