MUSCLE STRUCTURE AND PHYSIOLOGY

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Presentation transcript:

MUSCLE STRUCTURE AND PHYSIOLOGY J. Rosenbluth, April 2012

MUSCLE Skeletal muscle fibers Gross properties of skeletal muscle Contraction mechanism Excitation-contraction coupling Gross properties of skeletal muscle Pathology/Clinical examples

Myofibrils

Skeletal muscle band pattern

Double “antiparallel” array of myofilamnts (H.E.Huxley)

Sliding filament model

Myosin filament formation

Low-angle X-ray diffraction of skeletal muscle (meridional pattern)

Decorated F-actin

Antiparallel array of myofilaments

Double hexagonal array (vertebrate skeletal muscle)

Crossbridge position during relaxation (top) vs contraction (bottom)

Cross-bridge Cycle Attached Released Cocked Force generating

Triads (amphibian)

Skeletal muscle triad (amphibian)

Triad structure

Actin filament with Tr and Tm

Tropomyosin movement

Pennate Muscles

Length-Tension Relationship

Load-Velocity Relationship

Twitch vs Tetanic Tension

Fiber types (cat gastrocnemius)

Twitch contraction times

Skeletal Muscle Fatigue

“Winging” (facio-scapulo-humeral dystrophy)

“Pseudohypertrophy” (Duchenne dystrophy)

Charcot-Marie-Tooth disease

Spinal muscular atrophy