Overview AMR international initiatives – The Landscape Laura Marin JPIAMR Head of Secretariat Swedish Research Council MB Meeting 2018 Leuven, 23 October 2018

A Global Organisation 27 Countries have joined forces The European Commission (DG Research) is a full non voting member

International collaboration ORGANISATIONS FUNDERS UNGA, IAGC & Call for Action G7 Resolutions G20 Resolutions EU Council Conclusions AMR Global R&D Hub

Activities at International Level UNGA and IACG “IACG on AMR subgroup Innovation, R&D and Access”. They are doing an analysis of AMR R&D and access gaps and challenges. They published a discussion paper this summer and prepare UNGA recommendations for September 2019. UN AMR call for Action JPIAMR participated in the last event Berlin, October 2017 JPIAMR has been approached to be a co-host of the event in Ghana, November 2018 WHO Global Action Plan JPIAMR has been approach regarding pre-clinical pipeline analysis Meeting in January with WHO Europe TATFAR: Atlanta, March 2018 Panel discussion regarding future synergies among international initiatives

Activities at International Level G7, G20 resolutions Argentina October 2018: G20 mentions JPIAMR together with GARDP, UNITAD, CARB-X and the TB-Alliance, welcoming the work of these leading international initiatives. AMR R&D Global Hub Secretariats meeting, Stockholm, September 2018 Collaboration: data sharing for AMR investments dashboard PEW SPARK database Wellcome Observers at SEDRIC (Surveillance)

Activities at European Level 9FP – activities related to GPC and JPIs Chairs group Discussions on EC 9FP Horizon Europe New category for JPIs and new criteria; European Partnerships Future 9FP instruments: CSAs to support JPIs and call offices, New instrument? Co-programme? Co-fund? Drafts December 2018, candidates mid-2019 Common seminar JPIs on the future of Joint Programming The JPI chairs Forum September 20th Vienna. Joint collaboration Joint session at ECCMID Joint article EAAD Relations to AMR European Initiates European Joint Programme One Health in Zoonosis Partner of their Stakeholders Forum DG Sante Joint Action ”JAMRAI”

ANTIBIOTIC DRUG DEVELOPMENT AND INTERNATIONAL FUNDING INITIATIVES International Collaboration among Funders ANTIBIOTIC DRUG DEVELOPMENT AND INTERNATIONAL FUNDING INITIATIVES Phase I Phase II Phase III Basic Science Pre-clinical Market JPIAMR EU National Science Research Agencies EC FP / ERC EC - IMI / ND4BB US BARDA US NIH / NIAID Wellcome Trust CARB-X GARDR-P EIB’s InnovFin UK / China Global Innovation Fund REPAIR REPAIR Novo Holdings Fund Existed Prior 2016 Since 2017

Major AMR funding initiatives Prospect Budget USD 502m (2016-21) Euro 234m (2012-2024) Euro 270m (2017-23) USD 165m (2018-23) Euro 85m/800 m (2014-20) Products Novel therapeutics, diagnostics, preventatives, devices Novel therapeutics, diagnostics, surveillance, prevention, stewardship Novel therapeutics, Optimize antibiotics, Develop combinations Novel therapeutics, companion diagnostics Novel therapeutics Pathogens High priority defined by WHO and CDC, largely Gram-negatives WHO priority pathogens Member state national priorities WHO priority pathogen list, especially Gram-negatives High priority defined by WHO and CDC E. coli, K. pneumoniae, P. aeruginosa and A. baumannii Stages of development Hit-to-lead through end of Phase 1 Discovery research Any stage of development to patient access Lead optimization through end of Phase 1 Geography Global Europe & U.S. Europe Funding instruments Non-dilutive funding and expert support Research project grants, Networks, Virtual research institute Sponsor role (preclinical studies & clinical trials) Convertible loans and royalty-based Financial, in-kind and expertise support Funding allotments Flexible, with milestones; >30% cost share Direct funding 1m to 5m Direct funding and flexible partnerships USD 1m to 15m Flexible Conditions Stewardship and market access requirements Stewardship and access. Consider in/out licencing Stewardship and access requirements (in progress) Limited compensation when value generated

Activities at International Level Relations with international funders: CARB-X, GARP-D, Wellcome… Global AMR Funders Forum, London, December 2017 TBC, Brussels, February 2018 Joint MoU educational programmes Bootcamps Sessions at conferences CARB-X; GARDP; JPIAMR; REPAIR Novo fund

Thank you! www.jpiamr.eu @JPIAMR secretariat.jpiamr@vr.se