Foxo1 and Foxo3 help Foxp3 Immunity

Slides:

Advertisements

Similar presentations

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2 Meghan A. Koch, Kerri R. Thomas, Nikole R.

Advertisements

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells Julien Seneschal, Rachael A. Clark,

The CD70-CD27 Axis, a New Brake in the T Helper 17 Cell Response

Of Worms and Men: HLH-30 and TFEB Regulate Tolerance to Infection

FoxO: A New Addition to the ESC Cartel

CD5: A New Partner for IL-6

HIV-1 Latency by Transition

A Molecular Code for Imprinting Drug-Cue Associations

The Leptin Connection: Regulatory T Cells and Autoimmunity

PI3K Regulatory Subunits Lose Control in Cancer

Regulatory T Cells Stay on Course

The Birds, the Bees, and Innate Immunity

Notch: Filling a Hole in T Helper 2 Cell Differentiation

Mind Bomb Proteins in the Antiviral Arsenal

Treg's Alter Ego: An Accessory in Tumor Killing

Sterol-izing Innate Immunity

Taking T Cell Priming Down a Notch: Signaling through Notch Receptors Enhances T Cell Sensitivity to Antigen Timothy J. Thauland, Manish J. Butte Immunity

Yorkie and Scalloped: Partners in Growth Activation

Understanding Immunosuppression after Sepsis

A Flt3L Encounter: mTOR Signaling in Dendritic Cells

miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof

ILCs and T Cells Competing for Space: More Than a Numbers Game

T Helper 17 Cells Get the NOD

Checks and Balances: IL-23 in the Intestine

Stressed-Out HSCs Turn Up p38α and Purine to Proliferate

Germinal Centers: Gaining Strength from the Dark Side

Methed-Up FOXOs Can't In-Akt-ivate

Understanding Immunosuppression after Sepsis

Unraveling the Pros and Cons of Interferon-γ Gene Regulation

PU.1 Takes Control of the Dendritic Cell Lineage

Jan Philipp Junker, Alexander van Oudenaarden Molecular Cell

A Rogue Foxp3 Mutant Undermines Treg Cell Function

MicroRNAs in Tfh Cells: Micromanaging Inflammaging

Development and Maintenance of Regulatory T cells

Volume 20, Issue 1, Pages 3-5 (July 2011)

E Proteins Enforce Security Checkpoints in the Thymus

Michelle A. Linterman, Alice E. Denton Immunity

BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens

Regulatory T Cells Stay on Course

Maria A. Curotto de Lafaille, Juan J. Lafaille Immunity

T Cells Are Smad’ly in Love with Galectin-9

I Remember You: Epigenetic Priming in Epithelial Stem Cells

AKT/PKB Signaling: Navigating the Network

Plasma Cells for Hire: Prior Experience Required

A New FOXO Pathway Required for Leukemogenesis

Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells

Proteins Kinases: Chromatin-Associated Enzymes?

T Cell Cosignaling Molecules in Transplantation

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

Mark S. Sundrud, Anjana Rao Immunity

FOXO transcription factors

Volume 30, Issue 2, Pages (February 2009)

Michelle A. Linterman, Alice E. Denton Immunity

Cytokine Signaling Modules in Inflammatory Responses

Volume 35, Issue 6, Pages (December 2011)

Releasing the Brakes on Cancer Immunotherapy

Licensing PPARγ to Work in Macrophages

Regulatory T Cells GATA Have It

At 17, In-10's Passion Need Not Inflame

PTENtiating CFTR for Antimicrobial Immunity

Identity Crisis: It’s Not Just Foxp3 Anymore

Marking Emerging β- and γδ-Selected T Cells

The Regulatory T Cell Transcriptosome: E Pluribus Unum

IL-9 by INFERence Immunity

T Helper Cell Differentiation: Understanding the Needs of Hierarchy

Skp2, the FoxO1 hunter Cancer Cell

Tackling Resistance to PI3K Inhibition by Targeting the Epigenome

Presentation transcript:

Foxo1 and Foxo3 help Foxp3 Immunity Naganari Ohkura, Shimon Sakaguchi Immunity Volume 33, Issue 6, Pages 835-837 (December 2010) DOI: 10.1016/j.immuni.2010.12.004 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Foxo1 and Foxo3 Are Necessary for the Development and Function of Regulatory T cells The PI3K-Akt pathway is an upstream signal for the Foxo family members. It induces phosphorylation of Foxo transcriptional factors and their nuclear export into the cytoplasm. Foxo1 and Foxo3 bind to the promoter regions of Foxp3 and CTLA-4 and other genes. Those factors are required for the adequate gene expression of Foxp3 and its target genes, such as CTLA-4, in Treg cells. Immunity 2010 33, 835-837DOI: (10.1016/j.immuni.2010.12.004) Copyright © 2010 Elsevier Inc. Terms and Conditions