Duration of Dual Antiplatelet Therapy Post-ACS: Lessons from Clinical Trials.

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Presentation transcript:

Duration of Dual Antiplatelet Therapy Post-ACS: Lessons from Clinical Trials

Overview

Case Study

Acute Intervention

Current Medications

Physical Exam/Lab Findings

Subjective

Red Flags for Risk of Nonadherence?

Helpful Tips

Ubiquity of the Nonadherence Problem

Addressing Barriers With the Patient as Partner

DAPT Trial: Stent Thrombosis and MACCE

PEGASUS: HRs and Rates of the Primary Endpoint

Relative Risks for All-Cause Mortality in Good vs Poor Adherence to Major CV Medications

The Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART)

Major Efficacy and Safety Endpoints in PLATO and SWEDEHEART

Case Study: 12-Month Visit

Factors Favoring Longer DAPT

Calculation of a DAPT Score

Multivariable Prediction Model and Derivation of the Score

Effect of Long (12- to 24-Month) vs Short (3- to 6-month) DAPT (ACS Subgroup)

New Paradigms

Clinical Decision Making Vision for the Future

Patient Engagement

Future of Medication Adherence

Concluding Remarks

Abbreviations

Abbreviations (cont)