The Extent of Left Atrial Low-Voltage Areas Included in Pulmonary Vein Isolation Is Associated With Freedom from Recurrent Atrial Arrhythmia Dong Huang,

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The Extent of Left Atrial Low-Voltage Areas Included in Pulmonary Vein Isolation Is Associated With Freedom from Recurrent Atrial Arrhythmia Dong Huang, MD, Jing-bo Li, MD, Tarek Zghaib, MD, Esra Gucuk Ipek, MD, Muhammad Balouch, MD, David D. Spragg, MD, FHRS, Hiroshi Ashikaga, MD, PhD, Harikrishna Tandri, MD, Sunil K. Sinha, MD, Joseph E. Marine, MD, FHRS, Ronald D. Berger, MD, PhD, FHRS, Hugh Calkins, MD, FHRS, Saman Nazarian, MD, PhD, FHRS Canadian Journal of Cardiology Volume 34, Issue 1, Pages 73-79 (January 2018) DOI: 10.1016/j.cjca.2017.10.012 Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

Figure 1 Baseline low-voltage areas isolated by ablation. The color gradient reflects the graded changes in electrogram amplitude from purple at > 0.5 mV to red low-voltage areas at < 0.3 mV. Low-voltage areas were noted near the left inferior pulmonary vein ostium and on the posterior surface. As displayed in the figure, the low-voltage area located near the left inferior pulmonary vein was only partially isolated during pulmonary vein isolation. LIPV, left inferior pulmonary vein; LSPV, left superior pulmonary vein; RIPV, right inferior pulmonary vein; RSPV, right superior pulmonary vein. Canadian Journal of Cardiology 2018 34, 73-79DOI: (10.1016/j.cjca.2017.10.012) Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

Figure 2 Multivariable adjusted hazard ratio (HR) plot for atrial arrhythmia recurrence as a function of LVA-B isolated by ablation (LVA-I). The solid black line indicates multivariable adjusted HRs for atrial arrhythmia recurrence as a function of the LVA-I using restricted quadratic splines. The dashed lines delineate the upper and lower 95% confidence intervals. The horizontal grey line indicates an HR of 1.0. The model was adjusted for left atrial volume, CHA2DS2-VASc score, LVA-B, and AF type. AF, atrial fibrillation; CHA2DS2-VASc, Congestive Heart Failure, Hypertension, Age (≥ 75 years), Diabetes, Stroke/Transient Ischemic Attack, Vascular Disease, Age (65-74 years), Sex (Female) score. Canadian Journal of Cardiology 2018 34, 73-79DOI: (10.1016/j.cjca.2017.10.012) Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions