Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses Jeffrey M. Wilson, MD, PhD, Lisa Workman, BA,

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Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses Jeffrey M. Wilson, MD, PhD, Lisa Workman, BA, Alexander J. Schuyler, BS, BA, Sheryl L. Rifas-Shiman, MPH, Emily C. McGowan, MD, Emily Oken, MD, MPH, Diane R. Gold, MD, MPH, Robert G. Hamilton, PhD, Thomas A.E. Platts-Mills, MD, PhD Journal of Allergy and Clinical Immunology Volume 141, Issue 1, Pages 419-423.e5 (January 2018) DOI: 10.1016/j.jaci.2017.07.029 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, IgE sensitization to inhalant and food allergen extracts in 6- to 10-year-olds (n = 616) as measured by ImmunoCAP. B, Comparison of IgE results from microchip assay with results from the extract assay. C, Comparison of food-specific components with ImmunoCAP singleplex and ISAC. Class sensitization (on x-axis) was determined by extract testing and statistics reflect the χ2 test with Yates correction. Journal of Allergy and Clinical Immunology 2018 141, 419-423.e5DOI: (10.1016/j.jaci.2017.07.029) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Representative results of samples that were tested for IgE and IgG4 to cow's milk and peanut components by ImmunoCAP, and for IgE to components by ISAC. B, Specific IgG4 levels from samples that were positive to the component-relevant food specific IgE by extract testing where threshold of detection of specific IgG4 was 0.07 μg/mL. Data represent geometric means where error bars are the 95% CI. Values less than the threshold of detection are shown below the dotted line and are not included in the geometric mean. C, Milk (n = 20) and peanut (n = 23)-specific components were plotted for IgE and IgG4. Where IgE and IgG4 were less than the detection limit, they were depicted with the values 0.25 kU/L and 0.04 μg/mL, respectively. Journal of Allergy and Clinical Immunology 2018 141, 419-423.e5DOI: (10.1016/j.jaci.2017.07.029) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Overview of study design. The number of individuals or sera that were tested is depicted. Sera that were tested are represented in boldface. Journal of Allergy and Clinical Immunology 2018 141, 419-423.e5DOI: (10.1016/j.jaci.2017.07.029) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Component-specific IgG4 to IgE ratio in sera that were positive to the component-relevant food by extract testing. In cases in which IgG4 or IgE was not detected, a ratio could not be calculated. IgE was normalized with the formula 1 kU/L = 2.4 ng/mL. Journal of Allergy and Clinical Immunology 2018 141, 419-423.e5DOI: (10.1016/j.jaci.2017.07.029) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions