AR signaling in CTCs from CRPC patients treated with abiraterone acetate. AR signaling in CTCs from CRPC patients treated with abiraterone acetate. A,

Slides:

Advertisements

Similar presentations

A Randomized Trial Comparing Immediate versus Delayed Treatment of Anemia with Once-Weekly Epoetin Alfa in Patients with Non-small Cell Lung Cancer Scheduled.

Advertisements

Intermediate Atypical Carcinoma: Novel Histologic Subtype of mCRPC in Patients Resistant to Androgen Receptor Agonists CCO Independent Conference Highlights.

Volume 28, Issue 12, Pages (December 2016)

Frequency of JAK1 and JAK2 alterations and their association with overall survival in TCGA datasets. Frequency of JAK1 and JAK2 alterations and their association.

18F-FDG uptake is a noninvasive biomarker of combined MEK–mTORC1 inhibition. 18F-FDG uptake is a noninvasive biomarker of combined MEK–mTORC1 inhibition.

Effects of AG-221 treatment on survival and cell differentiation in an IDH2R140Q primary human AML xenograft model. Effects of AG-221 treatment on survival.

A Randomized Trial Comparing Immediate versus Delayed Treatment of Anemia with Once-Weekly Epoetin Alfa in Patients with Non-small Cell Lung Cancer Scheduled.

Ang II induces translocation of α-ENaC toward the apical membrane.

Volume 20, Issue 1, Pages (January 2012)

Volume 71, Issue 6, Pages (June 2017)

CHK1 downregulation upon ERG overexpression.

Kaplan–Meier survival curves of all-cause mortality in patients with idiopathic pulmonary fibrosis (IPF). Kaplan–Meier survival curves of all-cause mortality.

Whole-exome sequencing identifies NF1 mutations in tumors of melanoma patients exhibiting resistance to vemurafenib. Whole-exome sequencing identifies.

Li Xia, David S. Schrump, Jeffrey C. Gildersleeve

PD-1 expression on HCC-infiltrating B cells and its clinical significance. PD-1 expression on HCC-infiltrating B cells and its clinical significance. A–H,

Charles R. Nolan, Wajeh Y. Qunibi Kidney International

Microenvironmental immune cell signatures dictate clinical outcomes for PTCL-NOS by Takeshi Sugio, Kohta Miyawaki, Koji Kato, Kensuke Sasaki, Kyohei Yamada,

K.R. Julian Chun et al. JACEP 2017;3:

Nat. Rev. Urol. doi: /nrurol

Integrative analysis incorporating histopathology, transcript-based assessment of AR signaling and NEPC score, TP53 and RB1 genomic status, and clinical.

Overview of sample and patient characteristics for 444 tumors from 429 patients with mCRPC. Overview of sample and patient characteristics for 444 tumors.

Kaplan–Meier curves for the time until development of microscopic polyangiitis (MPA) (A) and for survival (B) in myeroperoxidase-antineutrophil cytoplasmic.

ChIP-seq analyses in primary in prostate tissue.

Stavros V. Konstantinides et al. JACC 2017;69:

Jeffrey J. Teuteberg et al. JCHF 2015;3:

TNFα is an important survival and growth signal for melanoma.

Fig. 4 Rational therapeutic modulation of the tumor microenvironment sensitizes tumors to ICB. Rational therapeutic modulation of the tumor microenvironment.

Fig. 1. Detection of circulating tumor DNA in CRPC patients.

Distinct molecular and clinical correlates of H3F3A mutation subgroups

In situ concurrent removal of MRSA bacteria and MRSA-secreting PFTs by RBC-PL-robots. In situ concurrent removal of MRSA bacteria and MRSA-secreting PFTs.

Serum bicarbonate increased by ≥3, ≥4, and ≥5 mEq/L in 52%, 39%, and 22% of patients, respectively, in the combined TRC101 dose group compared with 6%,

Correlation of RSPO expression to LGR5 expansion in gastric cancer.

Activity of SW480 qHTS runs and podophyllotoxin titration–response profiles of from library and control samples. Activity of SW480 qHTS runs and podophyllotoxin.

MiR-520d-3p is an independent positive prognostic factor in ovarian cancer. miR-520d-3p is an independent positive prognostic factor in ovarian cancer.

Association between RB pathway alterations and poor prognosis in early-stage lung adenocarcinoma patients. Association between RB pathway alterations and.

Progastrin expression in colonic tissues and Kaplan–Meier survival curves. Progastrin expression in colonic tissues and Kaplan–Meier survival curves. A,

mTORC1 is required for malignant transformation in the Eμ-Myc model.

Landscape of the TME in gastric cancer and characteristics of TME subtypes. Landscape of the TME in gastric cancer and characteristics of TME subtypes.

A, Overall survival of patients treated with CAR T cells (black line; n = 15). A, Overall survival of patients treated with CAR T cells (black line; n.

CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated with a longer survival. CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated.

IL-13Rα2 expression is associated to human colon cancer progression and poor survival of patients with colorectal cancer. IL-13Rα2 expression is associated.

Somatic mutational rates and survival analysis of IBD-CRC.

IDO deficiency delays the development of pulmonary metastases.

Kaplan-Meier survival plot for primary endpoint of arthritis development. Kaplan-Meier survival plot for primary endpoint of arthritis development. Arthritis-free.

Kaplan–Meier curves for PFS and OS (for patients treated with anti-PD-1/PD-L1 monotherapy). Kaplan–Meier curves for PFS and OS (for patients treated with.

Duration of treatment and intervals of radiographic and ctDNA response

Survival risk prediction analysis and application of the metastasis gene signature. Survival risk prediction analysis and application of the metastasis.

The responses of H292 and A549 lung cancer xenografts to hypofractionated radiation were enhanced by the ketogenic diet. The responses of H292 and A549.

PSMA expression in pre- and posttreatment prostate carcinoma serum.

Waterfall plot showing the relative change in median tumor FES uptake (SUVcor) in individual patients at the second scan compared with baseline. Waterfall.

MYC–HOXB7–HER2 predicts clinical outcome in breast cancer patients treated with tamoxifen. MYC–HOXB7–HER2 predicts clinical outcome in breast cancer patients.

BH3 profiling reveals BCL-2 dependence in ETP-ALL in a separate cohort of DFCI patient samples. BH3 profiling reveals BCL-2 dependence in ETP-ALL in a.

Change in FES uptake in the tumor during fulvestrant treatment.

Association of overall survival and PAP-specific (A, B) and PA2024-specific (C, D) CTL activity at week 26 using categorical (tertile) analysis and continuous.

Increased frequency and number of KLL-specific clonotypes in tumors is associated with improved MCC-specific survival. Increased frequency and number of.

The effects of AZD1775 and olaparib on DNA damage response signaling.

Fig. 5 Proportions of EpCAM+ systemic tumor cells correlate with the clinical outcome of patients with MBC. Proportions of EpCAM+ systemic tumor cells.

Ibrutinib decreases ofatumumab-mediated complement-dependent cytotoxicity. Ibrutinib decreases ofatumumab-mediated complement-dependent cytotoxicity. A,

Patient stratification using survival risk prediction and BCLC staging

Survival, subsequent therapies, and response.

A, Changes in BRAFV600E cfDNA allele fraction from baseline after one dose of treatment for 12 patients with serial samples available, classified according.

Expression of TGFβ ligands in GBM

Cross-species computational analyses of adverse treatment response.

Integrated analysis of gene expression and copy number alterations.

Transcriptome traits and clinical characteristics of TME phenotypes in the ACRG cohort. Transcriptome traits and clinical characteristics of TME phenotypes.

TME characteristics of TCGA-STAD subtype and cancer somatic genome.

Systemic inflammation in patients with severe neurotoxicity (NTX).

Transcriptome profiling of PD-L1 antibody–treated macrophages showed inflammatory phenotype, increased survival and proliferation, and decreased apoptosis.

Kaplan–Meier curves of relapse-free survival of the CAR-T cohort (left) and the HCT cohort (right) of 8 CAR-T patients and 12 HCT patients whose preceding.

A. B. C. D. Above median: Below median:

Presentation transcript:

AR signaling in CTCs from CRPC patients treated with abiraterone acetate. AR signaling in CTCs from CRPC patients treated with abiraterone acetate. A, pseudocolor density plots of multiparameter immunofluorescence AR signaling profiles of CTCs in a patient (Prost14) with CRPC, showing a decrease in the proportion of PSA+/PSMA− “AR-on” CTCs after the initiation of abiraterone acetate. B, Bar graphs depicting the results for this patient at serial time points following treatment. Corresponding CTC numbers and serum PSA levels are shown for pretreatment (pre) and at weeks following therapy. C, box plots showing composite data for relative proportions of AR signaling phenotypes in CTCs from patients that exhibit stable or declining proportion of “AR-on” CTCs after initiation of therapy (P = 0.56 for PSA+ only; P = 0.12 for PSA+/PSMA+; P = 0.14 for PSMA+ only). D, increase in the proportion of PSA+/PSMA− “AR-on” CTCs observed in a patient (Prost11) with CRPC after treatment with abiraterone acetate. E, bar graphs depicting the results for this patient. F, box plots showing composite data for relative proportions of AR signaling phenotypes in CTCs from patients that exhibit an increasing proportion of “AR-on” CTCs after initiation of therapy (P = 0.67 for PSA+ only; P = 0.67 for PSA+/PSMA+; P = 0.67 for PSMA+ only). G, Kaplan–Meier curves for overall survival in patients with CRPC treated with abiraterone acetate, according to baseline percentage of more than 10% “AR-mixed” CTCs (red) versus less than 10% “AR-mixed” CTCs [(blue) log-rank P = 0.048]. David T. Miyamoto et al. Cancer Discovery 2012;2:995-1003 ©2012 by American Association for Cancer Research