Pain, Donation-Related Symptoms and the Trajectory of Recovery in Children after Bone Marrow (BM) Donation Are Influenced By Age (Pre vs. Post-Puberty) and Sex: Primary Analysis of the Pediatric Toxicity Cohort of the Related Donor Safety Study (RDSafe)  Michael A. Pulsipher, MD, Brent R. Logan, PhD, Deidre M. Kiefer, M.P.H., Pintip Chitphakdithai, PhD, Galen E. Switzer, PhD, Marcie L. Riches, MD, J. Douglas Rizzo, MD, MS, Paolo Anderlini, MD, Susan F. Leitman, MD, James W. Varni, PhD, Hati Kobusingye, MS, RaeAnne M. Besser, BS, Bronwen E. Shaw, MD, PhD, Paul V. O'Donnell, MD, PhD, John P. Miller, MD, PhD, Rebecca J. Drexler, BS, AAS, Roberta J. King, MPH, Mary M. Horowitz, MD, MS, Dennis L. Confer, MD  Biology of Blood and Marrow Transplantation  Volume 22, Issue 3, Pages S93-S94 (March 2016) DOI: 10.1016/j.bbmt.2015.11.394 Copyright © 2016 Terms and Conditions

Figure 1 Skeletal Pain, Skeletal pain experienced by RDSafe pediatric BM donors by age group at baseline, collection and through follow up. (Skeletal pain represents pain in at least one of the following sites: back, bone, headache, hip, limb, joint, and neck). The severity of Skeletal pain is defined as the maximum grade among these pain sites. Biology of Blood and Marrow Transplantation 2016 22, S93-S94DOI: (10.1016/j.bbmt.2015.11.394) Copyright © 2016 Terms and Conditions

Figure 2 Highest Toxicity Level Across All Body Symptoms. Highest toxicity level of key symptoms (fever in the absence of signs of infection, fatigue, skin rash, local reactions, nausea, vomiting, anorexia, insomnia, dizziness, and syncope) experienced by RDSafe pediatric BM donors by age group, at baseline, collection and during follow up. Biology of Blood and Marrow Transplantation 2016 22, S93-S94DOI: (10.1016/j.bbmt.2015.11.394) Copyright © 2016 Terms and Conditions