IgG and IgG4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre.

Slides:

Advertisements

Similar presentations

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Advertisements

Early-life determinants of asthma from birth to age 20 years: A German birth cohort study Linus B. Grabenhenrich, MD, MPH, Hannah Gough, Andreas Reich,

Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years Linus B. Grabenhenrich, MD, MPH, Thomas Keil, MD, MSc, Andreas Reich,

Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban.

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever Laura Hatzler, Valentina Panetta,

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study Anna.

SQ-standardized sublingual grass immunotherapy: Confirmation of disease modification 2 years after 3 years of treatment in a randomized trial Stephen.

Theresa W. Guilbert, MD, David T. Mauger, PhD, David B

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts Alexander J. Hose, MA, MPH, Martin Depner, PhD, Sabina Illi, PhD,

Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema Sabine Zeller, MSc, Claudio Rhyner, PhD, Norbert Meyer, MD, Peter.

Ann-Marie M. Schoos, MD, PhD, Jacob D

Human seroreactivity to gut microbiota antigens

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD

Atopic sensitization in the first year of life

The component-specific to total IgE ratios do not improve peanut and hazelnut allergy diagnoses Linus Grabenhenrich, MD, MPH, Lars Lange, MD, Magdalena.

Effect of probiotics in prevention of atopic dermatitis is dependent on the intrinsic microbiota at early infancy Ekaterina Avershina, PhD, Raul Cabrera.

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study Anna.

No evidence of intrauterine sensitization against inhalant allergens

Allergy-related outcomes in relation to serum IgE: Results from the National Health and Nutrition Examination Survey Päivi M. Salo, PhD, Agustin.

Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy Albrecht Bufe, PhD, MD, Peter Eberle, MD, Eivy.

Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses Jeffrey M. Wilson, MD, PhD, Lisa Workman, BA,

Prevalence of allergic sensitization in the United States: Results from the National Health and Nutrition Examination Survey (NHANES) Päivi.

Early-life determinants of asthma from birth to age 20 years: A German birth cohort study Linus B. Grabenhenrich, MD, MPH, Hannah Gough, Andreas Reich,

In vivo allergenic activity of a hypoallergenic mutant of the major fish allergen Cyp c 1 evaluated by means of skin testing Nikolaos Douladiris, MD,

Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults Christian Lupinek, MD,

Prediction of peanut allergy in adolescence by early childhood storage protein-specific IgE signatures: The BAMSE population-based birth cohort Anna.

Simultaneous detection of total and allergen-specific IgE by using purified allergens in a fluorescent multiplex array Eva-Maria King, PhD, Lisa D. Vailes,

Peter M. Wolfgram, MD, David B. Allen, MD

Prenatal and postnatal genetic influence on lung function development

Theresa W. Guilbert, MD, David T. Mauger, PhD, David B

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: Implications for the development of vaccines against helminths David J. Diemert, MD,

Suppression of the basophil response to allergen during treatment with omalizumab is dependent on 2 competing factors Donald W. MacGlashan, MD, PhD,

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma Ingo Marenholz, PhD, Tamara Kerscher,

“Default” versus “pre-atopic” IgG responses to foodborne and airborne pathogenesis- related group 10 protein molecules in birch-sensitized and nonatopic.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

David C. LaFon, MD, Moon H. Nahm, MD

The widening black/white gap in asthma hospitalizations and mortality

Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children Yvonne Resch, MSc, Sven Michel, MSc, Michael Kabesch, MD,

Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: Implications for specific immunotherapy Salvatore Tripodi, MD, Tullio.

Cockroach allergens: Coping with challenging complexity

Autophagy: Nobel Prize 2016 and allergy and asthma research

Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban.

Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort Emily C. McGowan, MD, Gordon R. Bloomberg, MD,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Diagnosis and management of early asthma in preschool-aged children

Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life Daniela.

Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy Véronique Schulten, PhD,

Childhood-to-adolescence evolution of IgE antibodies to pollens and plant foods in the BAMSE cohort Magnus Wickman, MD, PhD, Anna Asarnoj, MD, PhD, Henrike.

Prenatal exposure to a farm environment modifies atopic sensitization at birth Markus Johannes Ege, MD, Ileana Herzum, MD, Gisela Büchele, MPH, Susanne.

Body mass index trajectory classes and incident asthma in childhood: Results from 8 European Birth Cohorts—a Global Allergy and Asthma European Network.

Identification of crab proteins that elicit IgE reactivity in snow crab–processing workers Beth V. Gill, MD, Timothy R. Rice, André Cartier, MD, Denise.

Day-care attendance, position in sibship, and early childhood wheezing: A population- based birth cohort study Nicolaos C. Nicolaou, MD, MPhil, Angela.

Early-life domestic aeroallergen exposure and IgE sensitization at age 4 years Matias Torrent, MD, MPH, Jordi Sunyer, MD, PhD, Laura Muñoz, PhD, Paul.

Contribution of dust mite and cat specific IgE to total IgE: Relevance to asthma prevalence Elizabeth A. Erwin, MD, Eva Rönmark, PhD, Kristin Wickens,

Atopic endotype in childhood

Päivi M. Salo, PhD, Samuel J. Arbes, DDS, MPH, PhD, Patrick W

Frederikke K. Lomholt, BMSc, Sune F. Nielsen, PhD, Børge G

Mediator release assay for assessment of biological potency of German cockroach allergen extracts Anna H. Nowak-Wegrzyn, MD, Ramon Bencharitiwong, BS,

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Personal and parental nativity as risk factors for food sensitization

Theresa W. Guilbert, MD, David T. Mauger, PhD, David B

Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood Adnan Custovic, MD, PhD, Lars Soderstrom,

Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence Marit Westman, MD, Christian Lupinek,

Carl Hamsten, MSc, PhD, Thi Anh T

Presentation transcript:

IgG and IgG4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre Allergy Study birth cohort Alina Schwarz, Valentina Panetta, MSc, Antonio Cappella, MD, Stephanie Hofmaier, MD, Laura Hatzler, MD, Alexander Rohrbach, Olympia Tsilochristou, MD, Carl-Peter Bauer, MD, Ute Hoffmann, MD, Johannes Forster, MD, Fred Zepp, MD, Antje Schuster, MD, Raffaele D'Amelio, MD, Ulrich Wahn, MD, Thomas Keil, MD, MSc, Susanne Lau, MD, Paolo Maria Matricardi, MD Journal of Allergy and Clinical Immunology Volume 138, Issue 5, Pages 1426-1433.e12 (November 2016) DOI: 10.1016/j.jaci.2016.01.057 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Prevalence of IgG responses to 91 allergenic molecules in 148 children of the MAS cohort at 2 years of age by IgE sensitization at 2 years of age. Red and blue bars show the prevalence of detectable IgG responses (≥0.1 ISU) at 2 years of age in children with or without IgE sensitization at 2 years of age. P values were calculated with χ2 or exact Fisher tests, when appropriate. Significant differences are highlighted as follows: *P < .05, **P < .01, and ***P < .001. The column on the right represents the exposure category (animal foods [red], vegetable foods [orange], inhaled [yellow], and others [grey]) to which the allergenic sources of individual molecules belong. The marked boxes (#) refer to molecules used for analyses at the source level. Journal of Allergy and Clinical Immunology 2016 138, 1426-1433.e12DOI: (10.1016/j.jaci.2016.01.057) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Prevalence and levels of IgG responses to allergenic sources in 148 children of the MAS cohort at 2 years of age by IgE sensitization at 2 years of age and main exposure route. Circles show the prevalence (y-axis) and levels (diameter) of detectable IgG responses (≥0.1 ISU) to allergenic sources (see the Methods section for definition) at 2 years of age in children with (red) or without (blue) IgE sensitization at 2 years of age. P values refer to comparisons of the prevalences and levels and were calculated with a χ2 and t test, respectively. Statistically significant differences are highlighted as follows: *P < .05 for prevalence and °P < .05 for level. Dpt, D pteronyssinus. Journal of Allergy and Clinical Immunology 2016 138, 1426-1433.e12DOI: (10.1016/j.jaci.2016.01.057) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Average prevalences and levels of IgG responses at 2 years of age to allergenic molecules by route of exposure in 123 nonsensitized and 25 IgE-sensitized 2-year-old children. Journal of Allergy and Clinical Immunology 2016 138, 1426-1433.e12DOI: (10.1016/j.jaci.2016.01.057) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Molecule selection at the source and category level. Journal of Allergy and Clinical Immunology 2016 138, 1426-1433.e12DOI: (10.1016/j.jaci.2016.01.057) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Prevalence of IgG4 responses (cutoff, 0.1 ISU) to allergenic molecules at 2 years of age in 148 children of the MAS cohort. Journal of Allergy and Clinical Immunology 2016 138, 1426-1433.e12DOI: (10.1016/j.jaci.2016.01.057) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Relationship between IgG (y-axis) and IgG4 (x-axis) levels to 91 allergenic molecules in a subset of 21 children of the MAS cohort. Each serum has been tested against the 91 molecules in parallel for IgG and IgG4 antibodies on the same day by the same operator. Overall, 1911 comparisons have been performed. Journal of Allergy and Clinical Immunology 2016 138, 1426-1433.e12DOI: (10.1016/j.jaci.2016.01.057) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Prevalence of IgG4 responses to allergenic molecules in 148 children of the MAS cohort at 2 years of age by means of IgE sensitization at 2 years of age. Only the molecules with at least 1 positive value (≥0.1 ISU) in either group are shown. P values were calculated with a χ2 test or exact Fisher test, when appropriate. Significant differences are highlighted as follows: *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology 2016 138, 1426-1433.e12DOI: (10.1016/j.jaci.2016.01.057) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Prevalence of IgG responses to allergenic molecules in 148 children of the MAS cohort at 2 years of age by IgE sensitization at 2 years of age. Only the results obtained in sera with no IgG4 response to the examined molecule have been taken into account. Therefore IgG4 antibodies do not contribute to the observed prevalence values. P values were calculated with a χ2 or exact Fisher test, when appropriate. Significant differences are highlighted as follows: *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology 2016 138, 1426-1433.e12DOI: (10.1016/j.jaci.2016.01.057) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E6 Prevalence of IgG responses to 91 allergenic molecules at 2 years of age in 148 children of the MAS cohort by IgE sensitization at 7 years of age. Red and blue bars are the prevalence of detectable IgG responses (≥0.1 ISU) at 2 years of age in children with or without IgE sensitization at 7 years of age. P values were calculated with a χ2 or exact Fisher test, when appropriate. Statistically significant differences are highlighted as follows: *P < .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology 2016 138, 1426-1433.e12DOI: (10.1016/j.jaci.2016.01.057) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E7 Prevalence and levels of IgG responses to 9 allergenic sources at 2 years of age in 148 children of the MAS cohort by IgE sensitization to the same sources at 7 years of age. Red and blue bars represent the prevalence (left panels) and levels (right panels) at 2 years of age of detectable IgG responses (IgG, ≥0.1 ISU) to foodborne (upper panels) and airborne (lower panels) allergenic sources in children with (red) or without (blue) IgE sensitization to the same source at 7 years of age. P values refer to comparison of the prevalences and were calculated with χ2 or Fisher exact tests for the separate sources and with a 2-level logistic mixed model to take into account multiple data per subjects for the grouped sources. P values for geometric means were calculated with t tests for unpaired data on logarithmic values for separate sources and with a 2-level linear mixed model on log IgG levels. Statistically significant differences are highlighted as follows: *P < .05. Journal of Allergy and Clinical Immunology 2016 138, 1426-1433.e12DOI: (10.1016/j.jaci.2016.01.057) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions