J. Lu, H. Zeng, H. Zheng, L. Yi, X. Guo, L. Liu, L. Sun, X. Tan, H

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Hand, foot and mouth disease in Guangdong, China, in 2013: new trends in the continuing epidemic  J. Lu, H. Zeng, H. Zheng, L. Yi, X. Guo, L. Liu, L. Sun, X. Tan, H. Li, C. Ke, J. Lin  Clinical Microbiology and Infection  Volume 20, Issue 7, Pages O442-O445 (July 2014) DOI: 10.1111/1469-0691.12468 Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 (a) Enterovirus-assoicated HFMD cases and enterovirus distribution in Guangdong Province, China, from 2008 to August 2013. The continuous line describes the total number of HFMD cases reported each year in Guangdong; the histogram shows the percentage of EVA71, CVA16 and other untyped enterovirus isolates in EV-positive samples. (b) Monthly distribution of CVA6, EVA71, CVA16 and other untyped enteroviruses in Guangdong Province, China, from 2012 to August 2013. The continuous line describes the total number of HFMD cases reported each month in Guangdong; the histogram shows the distribution of EVA71, CVA16, CVA6 and other untyped enterovirus isolates in each month. The high ratio of CVA6, which began to be detected in September of 2012, is highlighted with a dashed border. Clinical Microbiology and Infection 2014 20, O442-O445DOI: (10.1111/1469-0691.12468) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Phylogeneticanalysisofcoxsackievirus A6 partial (915 bp) viral capsid protein 1 nucleotide sequences (nt 2441–3357 according to Gdula strain AY421764), showing the relationships between the recent clinical CVA6 isolates from GenBank. Genbank accession numbers and location as well as year of virus isolation are included. Scale bar indicates branch distances; solid circles indicate strains sequenced in this study. Only bootstrap values of over 75% are shown. The virus strains isolated from 2008 to 2011 in China are marked in blue, and strains isolated from 2012 to 2013 in China are marked in red. CHN, China; ESP, Spain; FIN, Finland; FRA, France; IND, India; JPN, Japan; SH, Shanghai; SD, Shangdong; GD, Guangdong. Clinical Microbiology and Infection 2014 20, O442-O445DOI: (10.1111/1469-0691.12468) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions