Biochemistry Lecture 6.

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Presentation transcript:

Biochemistry Lecture 6

Structure of Proteins

Chapter 6, Figure 6.1, Three-dimensional folding of the protein myoglobin.

Structural Groups

Protein Folding

Chapter 6, Figure 6.2, The four levels of structural organization of proteins

Chapter 6, Figure 6.9, A Ramachandran plot of poly-L-alanine

Keratin

Collagen

Chapter 6, Figure 6.14, The structure of collagen fibers

Silk

Globular Proteins

X-Ray Crystallography

Nuclear Magnetic Resonance

Chapter 6, Figure 6A.9, Nuclear magnetic resonance spectroscopy (NMR)

Quaternary Structure

Folding and Denaturation

Chapter 6, Figure 6.24, Contribution to the free energy of folding of globular proteins

Monitoring Protein Folding

Denaturation… also known as “Cooking”

Chaperones

Misfolding Diseases

Mutation Impairs Proper Folding Sickle Cell Anemia Cystic Fibrosis

Contagious Misfolding: Prions