The Hepatobiliary Paracellular Pathway: A Paradigm Revisited

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The Hepatobiliary Paracellular Pathway: A Paradigm Revisited James L. Boyer Gastroenterology Volume 147, Issue 5, Pages 965-968 (November 2014) DOI: 10.1053/j.gastro.2014.09.018 Copyright © 2014 Terms and Conditions

Figure 1 The left panel illustrates the anatomical location of claudins forming the zonula occludens between epithelial cells. The right panel (modified with permission from reference 8) illustrates the topology and secondary structure of claudin-2 with its 4 predicted membrane spanning domains and 2 extracellular loops (ECL1 and ECL2) extending into the paracellular space. The cation binding site is immediately to the right of the GLW signature in ECL1. Gastroenterology 2014 147, 965-968DOI: (10.1053/j.gastro.2014.09.018) Copyright © 2014 Terms and Conditions