Figure 24.1 Phases of the cell cycle. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.2 Cyclin and cyclin-dependent kinase complexes of the human cell cycle. Redrawn based on diagram in Morgan, D. O. Annu. Rev. Cell. Dev. Biol. 13: 261, 1997. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.3 Regulation of M phase cyclin-dependent kinase (Cdk) activity. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.4 Reactions to leading to activation and inactivation of the cyclin dependent kinases (Cdks). Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.5 Role of Rb in cell cycle regulation. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.6 Regulation of the G1 to S transition by p53. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.7 Phosphorylation of tyrosine residues within cytoplasmic domains of PDGF receptor. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.8 Transmission of signal from PDFG receptor to Ras. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.9 GTP-Ras activates a kinase cascade. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.10 Outline of pathway for programmed cell death. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.11 Death receptor and mitochondrial pathways activate caspase cascade. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.12 Regulation of apoptosis by cytochrome c and other mitochondrial proteins. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.13 Regulation of p53 activity. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.14 Multiple pathways may be regulated by Ras. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.15 Ras downstream effectors regulation of apoptosis. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.16 Oncongene pathways. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.17 Tumor suppressor pathways. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.18 Secreted proteases generate pathway through basement membrane in metastasis. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.19 Induction of invasion and growth of blood vessel endothelial cells by tumor cell in angiogenesis. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.20 Each cancer has a different pattern of activated protooncogenes and deactivated tumor suppressor genes. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 24.21 Molecular analysis of laser microdissected cells characterizes the specific tumor. Reproduced and modified with permission from Simone, N. L., Bonner, R. F., Gillespie, J. W., Emmert-Buck, M. R., and Liotta., L. A. Laser-capture microdissection: opening the microscopic frontier to molecular analysis. Trends Genet. 14:272, 1998. Copyright (1998) Elsevier. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.