Prevention of ischemic spinal cord injury: Comparative effects of magnesium sulfate and riluzole Loïc Lang-Lazdunski, MD, Catherine Heurteaux, PhD, Hervé.

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Prevention of ischemic spinal cord injury: Comparative effects of magnesium sulfate and riluzole Loïc Lang-Lazdunski, MD, Catherine Heurteaux, PhD, Hervé Dupont, MD, Catherine Widmann, BA, Michel Lazdunski, PhD, DSc Journal of Vascular Surgery Volume 32, Issue 1, Pages 179-189 (July 2000) DOI: 10.1067/mva.2000.105960 Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Histopathological examination (original magnification, 400×). Representative photomicrographs of lumbar spinal cord sections stained with Klüver-Barrera stain from sham-operated (A), control (B), riluzole-treated (C), magnesium-treated (D), and riluzole plus magnesium-treated (E ) rabbits that underwent 40 minutes of spinal cord ischemia and 120 hours of reperfusion. The chosen sections for illustration of riluzole-treated and riluzole plus magnesium-treated groups (groups A and C) correspond to rabbits with a Tarlov score of 5. The chosen section for illustration of the magnesium-treated group (group B) corresponds to a rabbit with a Tarlov score of 2. A, Normal appearance of motor neurons in the ventral horn of a sham-operated rabbit. B, Necrotic motor neurons in the ventral horn of a control rabbit. C and E, Ventral horn motor neurons of riluzole-treated and riluzole plus magnesium-treated rabbits appear grossly normal. D, Most motor neurons from a magnesium-treated rabbit exhibit necrotic changes. Journal of Vascular Surgery 2000 32, 179-189DOI: (10.1067/mva.2000.105960) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Microtubule-associated protein-2 immunohistochemistry examination (original magnification, 400×). Microtubule-associated protein-2 immunoreactivity in lumbar spinal cord sections from sham-operated (A), control (B), riluzole-treated (C), magnesium-treated (D), and riluzole plus magnesium-treated (E) rabbits that underwent 40 minutes of spinal cord ischemia and 48 hours of reperfusion. The chosen sections for the illustration of the riluzole-treated and riluzole plus magnesium-treated groups correspond to rabbits with a Tarlov score of 5. The chosen section for illustration of the magnesium-treated group corresponds to a rabbit with a Tarlov score of 2. A, C, and E, Intense immunoreactivity was observed in the dendrites and neuronal perikaryon of sham-operated and riluzole-treated or riluzole plus magnesium-treated rabbits. B, The spinal cord of a control rabbit exhibits a complete loss of microtubule-associated protein-2 immunoreactivity in ventral and dorsal horns. D, Magnesium treatment did not prevent the loss of microtubule-associated protein-2 immunoreactivity in the ventral horns of this rabbit. Journal of Vascular Surgery 2000 32, 179-189DOI: (10.1067/mva.2000.105960) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions